A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.

Details

Serval ID
serval:BIB_99C034574B09
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.
Journal
Cell reports
Author(s)
Jourdain Alexis
Publication state
Published
Issued date
19/02/2015
Language
english
Abstract
The mitochondrial genome relies heavily on post-transcriptional events for its proper expression, and misregulation of this process can cause mitochondrial genetic diseases in humans. Here, we report that a novel translational variant of Fas-activated serine/threonine kinase (FASTK) co-localizes with mitochondrial RNA granules and is required for the biogenesis of ND6 mRNA, a mitochondrial-encoded subunit of the NADH dehydrogenase complex (complex I). We show that ablating FASTK expression in cultured cells and mice results specifically in loss of ND6 mRNA and reduced complex I activity in vivo. FASTK binds at multiple sites along the ND6 mRNA and its precursors and cooperates with the mitochondrial degradosome to ensure regulated ND6 mRNA biogenesis. These data provide insights into the mechanism and control of mitochondrial RNA processing within mitochondrial RNA granules.
Pubmed
Create date
13/04/2021 17:25
Last modification date
14/04/2021 6:37
Usage data