I.V. midazolam as an induction agent for anaesthesia: a study in volunteers

Details

Serval ID
serval:BIB_99B9B88AFBF3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
I.V. midazolam as an induction agent for anaesthesia: a study in volunteers
Journal
British Journal of Anaesthesia
Author(s)
Forster  A., Gardaz  J. P., Suter  P. M., Gemperle  M.
ISSN
0007-0912 (Print)
Publication state
Published
Issued date
09/1980
Volume
52
Number
9
Pages
907-11
Notes
Journal Article --- Old month value: Sep
Abstract
The central nervous and cardiovascular effects of midazolam 0.15 mg kg-1 were studied in 20 healthy, unpremedicated volunteers (10 male and 10 female). No important side-effects were noted and the venous tolerance to midazolam was excellent. Three minutes after injection mean systolic arterial pressure decreased from 121 +/- (SEM) 2 mm Hg to 115 +/- (SEM) 2 mm Hg and diastolic pressure from 78 +/- 2 to 70 +/0 2 mm Hg (P < 0.05), and these effects persisted for at least 20 min. Heart rate increased from 77 +/- 4 beat min-1 to 90 +/- 3 and 88 +/- 3 beat min-1 and 3 min after the injection (P < 0.05). Anterograde amnesia (40 +/- 3 min duration) and drowsiness (lasting 128 +/- 23 min) were observed in all subjects. Loss of the eyelash reflex and apnoea were observed more often in the male group than in the female subjects. Midazolam 0.15 mg kg-1 was not sufficient to induce anaesthesia reliably in healthy unpremedicated volunteers.
Keywords
Adult Anesthesia, Intravenous/*methods *Anti-Anxiety Agents/pharmacology *Benzodiazepines/pharmacology Brain/drug effects Female Hemodynamic Processes/drug effects Humans Male Midazolam Sex Factors
Pubmed
Web of science
Create date
28/01/2008 10:48
Last modification date
20/08/2019 15:01
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