The association between inflammatory biomarkers and metabolically healthy obesity depends of the definition used.

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State: Public
Version: author
Serval ID
serval:BIB_99AA0C4CD6B6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The association between inflammatory biomarkers and metabolically healthy obesity depends of the definition used.
Journal
European Journal of Clinical Nutrition
Author(s)
Marques-Vidal P., Velho S., Waterworth D., Waeber G., von Känel R., Vollenweider P.
ISSN
1476-5640 (Electronic)
ISSN-L
0954-3007
Publication state
Published
Issued date
2012
Volume
66
Number
4
Pages
426-435
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
BACKGROUND/OBJECTIVES: To assess the distribution of interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF)-α and C-reactive protein (CRP) according to the different definitions of metabolically healthy obesity (MHO).
SUBJECTS/METHODS: A total of 881 obese (body mass index (BMI) > or =30 kg/m2) subjects derived from the population-based CoLaus Study participated in this study. MHO was defined using six sets of criteria including different combinations of waist, blood pressure, total high-density lipoprotein cholesterol or low-density lipoprotein -cholesterol, triglycerides, fasting glucose, homeostasis model, high-sensitivity CRP, and personal history of cardiovascular, respiratory or metabolic diseases. IL-1β, IL-6 and TNF-α were assessed by multiplexed flow cytometric assay. CRP was assessed by immunoassay.
RESULTS: On bivariate analysis some, but not all, definitions of MHO led to significantly lower levels of IL-6, TNF-α and CRP compared with non-MH obese subjects. Most of these differences became nonsignificant after multivariate analysis. An posteriori analysis showed a statistical power between 9 and 79%, depending on the inflammatory biomarker and MHO definition considered. Further increasing sample size to overweight+obese individuals (BMI > or =25 kg/m2, n=2917) showed metabolically healthy status to be significantly associated with lower levels of CRP, while no association was found for IL-1β. Significantly lower IL-6 and TNF-α levels were also found with some but not all MHO definitions, the differences in IL-6 becoming nonsignificant after adjusting for abdominal obesity or percent body fat.
CONCLUSIONS: MHO individuals present with decreased levels of CRP and, depending on MHO definition, also with decreased levels in IL-6 and TNF-α. Conversely, no association with IL-1β levels was found.
Keywords
Adipose Tissue/metabolism, Adult, Aged, Biological Markers/blood, Body Mass Index, C-Reactive Protein/analysis, Female, Humans, Inflammation/blood, Inflammation/complications, Interleukin-1beta/blood, Interleukin-6/blood, Linear Models, Lipoproteins, HDL/blood, Lipoproteins, LDL/blood, Male, Middle Aged, Multivariate Analysis, Obesity/blood, Obesity/complications, Prevalence, Triglycerides/blood, Tumor Necrosis Factor-alpha/blood
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2011 12:27
Last modification date
20/08/2019 16:01
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