Intergenic lncRNAs and the evolution of gene expression.

Details

Serval ID
serval:BIB_99A1445C5F1D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Intergenic lncRNAs and the evolution of gene expression.
Journal
Current Opinion in Genetics and Development
Author(s)
Marques A.C., Ponting C.P.
ISSN
1879-0380 (Electronic)
ISSN-L
0959-437X
Publication state
Published
Issued date
2014
Volume
27
Pages
48-53
Language
english
Abstract
Eukaryote genomes encode a surprisingly large number of noncoding transcripts. Around two-thirds of human transcribed loci do not encode protein, and many are intergenic and produce long (>200 nucleotides) noncoding RNAs (lncRNAs). Extensive analyses using comparative genomics and transcriptomics approaches have established that lncRNA sequence and transcription tend to turn over rapidly during evolution. Our appreciation of the biological roles of lncRNAs, based only on a handful of transcripts with well-characterized functions, is that lncRNAs have diverse roles in regulating gene expression. These proposed roles together with their rapid rates of evolution suggest that lncRNAs could contribute to the divergent expression patterns observed among species and potentially to the origin of new traits.
Keywords
Animals, Evolution, Molecular, Gene Expression, Genetic Variation, Humans, Phenotype, RNA, Long Noncoding/genetics
Pubmed
Web of science
Create date
27/10/2014 14:43
Last modification date
20/08/2019 15:01
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