Kardiale Interaktionen zwischen Ketanserin und dem Calcium-Antagonisten Nifedipin [Cardiac interactions between ketanserin and the calcium antagonist nifedipine].

Details

Serval ID
serval:BIB_997E44EA5891
Type
Article: article from journal or magazin.
Collection
Publications
Title
Kardiale Interaktionen zwischen Ketanserin und dem Calcium-Antagonisten Nifedipin [Cardiac interactions between ketanserin and the calcium antagonist nifedipine].
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Alberio L., Beretta-Piccoli C., Tanzi F., Koch P., Zehender M.
ISSN
0036-7672 (Print)
ISSN-L
0036-7672
Publication state
Published
Issued date
1992
Peer-reviewed
Oui
Volume
122
Number
45
Pages
1723-1727
Language
german
Notes
Publication types: English Abstract ; Journal Article Publication Status: ppublish
Abstract
Ketanserin and calcium antagonists are frequently used for the treatment of arterial hypertension in the elderly. The possibility that combined treatment with ketanserin and the calcium antagonist nifedipine have a pro-arrhythmic effect was investigated in 20 normal volunteers aged > 60 years with normal or slightly elevated blood pressure. Each subject received monotherapy with ketanserin or nifedipine for 1 week and the combined treatment during the following week. Clinical and biochemical parameters, ECG and 24-hour ECG recording were monitored before and at the end of the first and second treatment weeks. Ketanserin and nifedipine given in monotherapy or in combination did not modify, on average, blood pressure, heart rate, the biochemical variables and the QT interval. In the 24-hour ECG recordings, 2 normal subjects developed a marked increase in the frequency of ventricular ectopics, couplets and ventricular tachycardia after combined treatment. Therefore, the present investigation does not exclude the possibility that combined treatment with ketanserin and nifedipine could increase the prevalence of arrhythmia in some elderly patients.
Keywords
Aged, Arrhythmias, Cardiac/chemically induced, Blood Pressure/drug effects, Cardiac Complexes, Premature/chemically induced, Drug Interactions, Drug Therapy, Combination, Electrocardiography, Female, Heart Rate/drug effects, Humans, Hypertension/drug therapy, Ketanserin/administration & dosage, Ketanserin/adverse effects, Male, Middle Aged, Nifedipine/administration & dosage, Nifedipine/adverse effects
Pubmed
Web of science
Create date
10/02/2015 11:08
Last modification date
20/08/2019 15:00
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