The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.

Details

Serval ID
serval:BIB_9978559CDF5D
Type
Article: article from journal or magazin.
Collection
Publications
Title
The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.
Journal
British journal of haematology
Author(s)
Tosetto A., Missiaglia E., Frezzato M., Rodeghiero F.
ISSN
0007-1048 (Print)
ISSN-L
0007-1048
Publication state
Published
Issued date
06/1997
Peer-reviewed
Oui
Volume
97
Number
4
Pages
804-806
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We evaluated the hypothesis that a common polymorphism of the methylenetetrahydrofolate reductase gene (C677T), which results in increased levels of plasma homocysteine, may be a putative risk factor for venous thromboembolism (VT). Sixty-five cases of VT and 130 controls, both identified within the framework of an epidemiologic survey on thrombophilia, the Vicenza Thrombophilia and Arteriosclerosis (VITA) Project, were genotyped for the mutation. No increased risk of VT was found in carriers of the mutation. We conclude that screening for the C677T mutation of the methylenetetrahydrofolate reductase gene should not be recommended in unselected patients with VT.
Keywords
Adult, Aged, Female, Gene Frequency, Heterozygote, Homozygote, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2), Middle Aged, Mutation, Oxidoreductases Acting on CH-NH Group Donors/genetics, Thromboembolism/genetics
Pubmed
Web of science
Open Access
Yes
Create date
26/09/2023 9:53
Last modification date
04/10/2023 14:37
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