Prevention of arrhythmias after noncardiac thoracic operations: flecainide versus digoxin

Details

Serval ID
serval:BIB_996F8027AA1D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevention of arrhythmias after noncardiac thoracic operations: flecainide versus digoxin
Journal
Annals of Thoracic Surgery
Author(s)
Borgeat  A., Petropoulos  P., Cavin  R., Biollaz  J., Munafo  A., Schwander  D.
ISSN
0003-4975 (Print)
Publication state
Published
Issued date
06/1991
Volume
51
Number
6
Pages
964-7; discussion 967-8
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Jun
Abstract
Cardiac arrhythmias are known complications of thoracic operations. The prophylactic value of flecainide administered as a constant-rate, intravenous infusion (0.15 mg.kg-1.h-1) after a loading dose (2 mg.kg-1) was compared with digoxin (10 micrograms.kg-1 for 12 hours, then 0.25 mg.24 h-1) in a randomized study in 30 patients using Holter monitoring during the first 72 hours after operation. Drug monitoring was performed every day to keep a serum level of flecainide of 200 to 600 ng.mL-1 and a digoxin level of 0.8 to 2 ng.mL-1. Failure, defined as the appearance of atrial fibrillation or flutter or the development of complex ventricular arrhythmias (Lown IVb and V), was observed in one patient in the flecainide group (7%) and in 7 patients in the digoxin group (47%) (p less than 0.05). It is concluded that flecainide is more efficient than digoxin in preventing and treating cardiac arrhythmias after thoracic operations. At the dosage used side effects related to flecainide or digoxin were not observed.
Keywords
Arrhythmia/diagnosis/etiology/*prevention & control Digoxin/administration & dosage/*therapeutic use Electrocardiography, Ambulatory Flecainide/administration & dosage/*therapeutic use Humans Lung/surgery Postoperative Complications/*prevention & control *Thoracic Surgery
Pubmed
Web of science
Create date
25/01/2008 10:41
Last modification date
20/08/2019 15:00
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