Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity.

Details

Serval ID
serval:BIB_995EAF2BF378
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity.
Journal
Oncogene
Author(s)
Fiore E., Fusco C., Romero P., Stamenkovic I.
ISSN
0950-9232,
Publication state
Published
Issued date
2002
Volume
21
Number
34
Pages
5213-5223
Language
english
Notes
Publication types: In Vitro ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
Shedding of intercellular adhesion molecule 1 (ICAM-1) is believed to play a role in tumor cell resistance to cell-mediated cytotoxicity. However, the mechanism whereby ICAM-1 is shed from the surface of tumor cells remains unclear. In this study, we have addressed the possibility that matrix metalloproteinases are implicated in ICAM-1 shedding. Our observations suggest a functional relationship between ICAM-1 and matrix metalloproteinase 9 (MMP-9) whereby ICAM-1 provides a cell surface docking mechanism for proMMP-9, which, upon activation, proteolytically cleaves the extracellular domain of ICAM-1 leading to its release from the cell surface. MMP-9-dependent shedding of ICAM-1 is found to augment tumor cell resistance to natural killer (NK) cell-mediated cytotoxicity. Taken together, our observations propose a mechanism for ICAM-1 shedding from the cell surface and provide support for MMP involvement in tumor cell evasion of immune surveillance.
Keywords
Cell Adhesion, Collagen Type IV/metabolism, Cytotoxicity, Immunologic/immunology, DNA Primers/chemistry, Drug Resistance, Neoplasm, Gelatin/metabolism, HL-60 Cells/immunology, HL-60 Cells/metabolism, Humans, Immunity, Cellular, Intercellular Adhesion Molecule-1/metabolism, Killer Cells, Natural/immunology, Leukemia, Promyelocytic, Acute/immunology, Matrix Metalloproteinase 9/physiology, Mutation, Polymerase Chain Reaction, Precipitin Tests, Transfection, Tumor Cells, Cultured/immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:27
Last modification date
20/08/2019 15:00
Usage data