Modulation of epileptiform discharges in the rat limbic system in vitro by noradrenergic agents

Details

Serval ID
serval:BIB_98E4B9CABAEF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Modulation of epileptiform discharges in the rat limbic system in vitro by noradrenergic agents
Journal
Neuroscience Letters
Author(s)
Stoop Ron, Epiney Sandrine, Meier Evelyne, Pralong Etienne
ISSN
0304-3940
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
287
Number
1
Pages
5-8
Language
english
Notes
SAPHIRID:67372
Abstract
Application of bicuculline (20 microm) in a horizontal slice preparation of the rat limbic system induced epileptiform discharges ('bursts') that spread from the hippocampus to the entorhinal cortex (EC) and the basolateral amygdala (BLA). These bursts were time locked, with the CA3-CA2 regions discharging first at a 0.1+/-0. 008Hz (n=30 slices) frequency, followed after 27+/-3 ms by the superficial layers of the EC and after 44.3+/-3 ms by the BLA. Application of 50 microM noradrenaline (NA) for 4 min reduced the burst frequency to 40% of its initial value. Pharmacological study of NA action on burst frequency revealed that it consisted of a beta adrenoreceptor-mediated increase and an alpha(2) adrenoreceptor-mediated decrease of epileptiform bursting frequency.
Pubmed
Web of science
Create date
11/03/2008 11:57
Last modification date
20/08/2019 16:00
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