Inflammation in schizophrenia: A question of balance.

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State: Public
Version: author
Serval ID
serval:BIB_98DDFA1D11DC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Inflammation in schizophrenia: A question of balance.
Journal
Neuroscience and Biobehavioral Reviews
Author(s)
Leza J.C., García-Bueno B., Bioque M., Arango C., Parellada M., Do K., O'Donnell P., Bernardo M.
ISSN
1873-7528 (Electronic)
ISSN-L
0149-7634
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
55
Pages
612-626
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
In the past decade, there has been renewed interest in immune/inflammatory changes and their associated oxidative/nitrosative consequences as key pathophysiological mechanisms in schizophrenia and related disorders. Both brain cell components (microglia, astrocytes, and neurons) and peripheral immune cells have been implicated in inflammation and the resulting oxidative/nitrosative stress (O&NS) in schizophrenia. Furthermore, down-regulation of endogenous antioxidant and anti-inflammatory mechanisms has been identified in biological samples from patients, although the degree and progression of the inflammatory process and the nature of its self-regulatory mechanisms vary from early onset to full-blown disease. This review focuses on the interactions between inflammation and O&NS, their damaging consequences for brain cells in schizophrenia, the possible origins of inflammation and increased O&NS in the disorder, and current pharmacological strategies to deal with these processes (mainly treatments with anti-inflammatory or antioxidant drugs as add-ons to antipsychotics).
Keywords
Animals, Anti-Inflammatory Agents/therapeutic use, Antioxidants/therapeutic use, Antipsychotic Agents/therapeutic use, Brain/metabolism, Humans, Inflammation/complications, Inflammation/metabolism, Neuroglia/metabolism, Neurons/metabolism, Nitric Oxide Synthase/metabolism, Oxidative Stress, Schizophrenia/complications, Schizophrenia/drug therapy
Pubmed
Web of science
Create date
22/06/2015 13:32
Last modification date
20/08/2019 16:00
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