Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)-from morphology to molecular testing.

Details

Serval ID
serval:BIB_98DC0041D166
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)-from morphology to molecular testing.
Journal
Journal of thoracic disease
Author(s)
Righi L., Franzi F., Montarolo F., Gatti G., Bongiovanni M., Sessa F., La Rosa S.
ISSN
2072-1439 (Print)
ISSN-L
2072-1439
Publication state
Published
Issued date
05/2017
Peer-reviewed
Oui
Volume
9
Number
Suppl 5
Pages
S395-S404
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
In recent years, endobronchial ultrasound-guided TBNA (EBUS-TBNA) has emerged as an innovative technique for diagnosis and staging of lung cancer and has been successfully introduced into daily clinical practice with several advantages including minimally invasive approach, safe, cost-effective, real time image guidance, broad sampling capability, and rapid on-site evaluation (ROSE). Both cytological and histological approach could be useful to have material for diagnosis, immunohistochemical and molecular analyses which may be very important for targeted therapy with successful rate ranging from 89% to 98%. The utility of ROSE during EBUS-TBNA has been matter of debate. Indeed, although some evidence concluded that ROSE does not increase the diagnostic efficacy of EBUS-TBNA, other demonstrated that it improves the diagnostic yield of the procedure up to 30%, allows to avoid repetition of additional diagnostic procedures and reduces risk of complications. Furthermore the sample preparation by cytopathologist is optimized with the aid of direct macroscopic inspection, optimal smearing techniques, and triage of the sample permitting to obtain adequate tissue for diagnosis, ancillary techniques and molecular testing, when needed. Some pathological issues on EBUS-TBNA are reviewed and discussed with particular focus on ROSE and molecular testing.

Keywords
ALK, EGFR, Endobronchial ultrasound-guided (EBUS), immunohistochemistry (IHC), lung cancer, transbronchial needle aspiration (TBNA)
Pubmed
Web of science
Create date
14/06/2017 10:09
Last modification date
20/08/2019 16:00
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