Theory of mind impairment in patients with behavioural variant fronto-temporal dementia (bv-FTD) increases caregiver burden.

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Serval ID
serval:BIB_98B457FF4EC5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Theory of mind impairment in patients with behavioural variant fronto-temporal dementia (bv-FTD) increases caregiver burden.
Journal
Age and Ageing
Author(s)
Brioschi Guevara A., Knutson K.M., Wassermann E.M., Pulaski S., Grafman J., Krueger F.
ISSN
1468-2834 (Electronic)
ISSN-L
0002-0729
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
44
Number
5
Pages
891-895
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
BACKGROUND: Theory of mind (ToM), the capacity to infer the intention, beliefs and emotional states of others, is frequently impaired in behavioural variant fronto-temporal dementia patients (bv-FTDp); however, its impact on caregiver burden is unexplored.
SETTING: National Institute of Neurological Disorders and Stroke, National Institutes of Health.
SUBJECTS: bv-FTDp (n = 28), a subgroup of their caregivers (n = 20) and healthy controls (n = 32).
METHODS: we applied a faux-pas (FP) task as a ToM measure in bv-FTDp and healthy controls and the Zarit Burden Interview as a measure of burden in patients' caregivers. Patients underwent structural MRI; we used voxel-based morphometry to examine relationships between regional atrophy and ToM impairment and caregiver burden.
RESULTS: FP task performance was impaired in bv-FTDp and negatively associated with caregiver burden. Atrophy was found in areas involved in ToM. Caregiver burden increased with greater atrophy in left lateral premotor cortex, a region associated in animal models with the presence of mirror neurons, possibly involved in empathy.
CONCLUSION: ToM impairment in bv-FTDp is associated with increased caregiver burden.
Keywords
Atrophy, Caregivers/psychology, Case-Control Studies, Cognition, Cost of Illness, Female, Frontal Lobe/pathology, Frontal Lobe/physiopathology, Frontotemporal Dementia/diagnosis, Frontotemporal Dementia/physiopathology, Humans, Intelligence, Interviews as Topic, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Temporal Lobe/pathology, Temporal Lobe/physiopathology, Theory of Mind
Pubmed
Web of science
Open Access
Yes
Create date
13/10/2015 18:58
Last modification date
23/06/2020 6:26
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