The Influence of Training Load on Hematological Athlete Biological Passport Variables in Elite Cyclists.

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Version: Final published version
License: CC BY-SA 4.0
Serval ID
serval:BIB_989625634F53
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Influence of Training Load on Hematological Athlete Biological Passport Variables in Elite Cyclists.
Journal
Frontiers in sports and active living
Author(s)
Astolfi T., Crettaz von Roten F., Kayser B., Saugy M., Faiss R.
ISSN
2624-9367 (Electronic)
ISSN-L
2624-9367
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
3
Pages
618285
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The hematological module of the Athlete Biological Passport (ABP) is used in elite sport for antidoping purposes. Its aim is to better target athletes for testing and to indirectly detect blood doping. The ABP allows to monitor hematological variations in athletes using selected primary blood biomarkers [hemoglobin concentration (Hb) and reticulocyte percentage (Ret%)] with an adaptive Bayesian model to set individual upper and lower limits. If values fall outside the individual limits, an athlete may be further targeted and ultimately sanctioned. Since (Hb) varies with plasma volume (PV) fluctuations, possibly caused by training load changes, we investigated the putative influence of acute and chronic training load changes on the ABP variables. Monthly blood samples were collected over one year in 10 male elite cyclists (25.6 ± 3.4 years, 181 ± 4 cm, 71.3 ± 4.9 kg, 6.7 ± 0.8 W <sup>.</sup> kg <sup>-1</sup> 5-min maximal power output) to calculate individual ABP profiles and monitor hematological variables. Total hemoglobin mass (Hbmass) and PV were additionally measured by carbon monoxide rebreathing. Acute and chronic training loads-respectively 5 and 42 days before sampling-were calculated considering duration and intensity (training stress score, TSS <sup>TM</sup> ). (Hb) averaged 14.2 ± 0.0 (mean ± SD) g <sup>.</sup> dL <sup>-1</sup> (range: 13.3-15.5 g·dl <sup>-1</sup> ) over the study with significant changes over time (P = 0.004). Hbmass was 1030 ± 87 g (range: 842-1116 g) with no significant variations over time (P = 0.118), whereas PV was 4309 ± 350 mL (range: 3,688-4,751 mL) with a time-effect observed over the study time (P = 0.014). Higher acute-but not chronic-training loads were associated with significantly decreased (Hb) (P <0.001). Although individual hematological variations were observed, all ABP variables remained within the individually calculated limits. Our results support that acute training load variations significantly affect (Hb), likely due to short-term PV fluctuations, underlining the importance of considering training load when interpreting individual ABP variations for anti-doping purposes.
Keywords
anti-doping, blood, cycling, hemoglobin, plasma volume, training load
Pubmed
Open Access
Yes
Create date
18/03/2021 10:31
Last modification date
14/04/2021 6:36
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