Strategies for multivessel revascularization in patients with diabetes.
Details
Serval ID
serval:BIB_989240271272
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Strategies for multivessel revascularization in patients with diabetes.
Journal
The New England journal of medicine
Working group(s)
FREEDOM Trial Investigators
Contributor(s)
Pepine C.J., Brinker J., Chan E.C., Clark C., Fowler S., Reitz B., Schulman K., Fuster V., Adams D., Bertrand M., Buller C., Buse J., Cohen D., Dangas G., Domanski M., Farkouh M.E., Flather M., Herrmann H., Holmes D.R., King S.B., Mack M., Moses J.W., Nesto R., Schaff H., Sherman D., Siami F.S., Sleeper L., Smith C., Sousa E., Stone G.W., Weinberger J., Williams D., Sharma S., Adams D., Weinberger J., Breen T., Kini A., Filsoufi F., Kim M., Moreno P., Krishnan P., Ricci D., Fradet G., Teal P., Elliott T., Wood D.A., Hamburger J., Saw J., Ramanathan K., Janusz M., Cook R.C., Fung T., Gudas V., Weisz G., Smith C., Willey J., Goland R., Stewart A., Kreps E., Stone G., Moses J., Rabbani L., Apfelbaum M., Leon M., Oz M., Argenziano M., Collins M., Mehran R., Sherman W., Gray W., Naka Y., Feldman T., Alexander J.C., Munson R., Blomeier H., Kogan A., Levisay J., Salinger M., Sanborn T., Turco M.A., Militano T., Iqbal A., Poltorak M., Gonzalez O., Brill D.M., Chatrathi S., Kelley L., Kenigsberg A., Kumkumian G., Qazi A., Shawl F.A., Srinivas A., Ballard W., Gott J., Robertson D.G., Kalynych A.M., Reddy B.K., Brown C., Wilmer C.I., Wickliffe C.W., Karmpaliotis D., Carlson H., Kauten J., Taylor K.G., Corrigan V., Rajagopal V., Mashman W.E., Knapp W., Blincoe W.A., Brown W.M., Robb J.F., Dacey L., Lukovits T.G., Comi R.J., Kaplan A.V., Hettleman B., Friedman B.J., Jayne J., Sanders J.H., Niles I.I., Nugent W., Mavromatis K., Vega D., Wilmont G., Brown W.V., Nair R., Markowitz A., Pundik S., Herowitz K., Cunningham M., Lassar T., Pompili V., Cutlip D., Hagberg R., Abrahamson M., Dow C., Leeman D., Pinto D., Ho K., Laham R., Shubrooks S., Colyer W., Tietjen G., Cooper C., Burket M., Sharaf B., Dawn A.J., Quesada R., Moreno N.L., Herskowitz B., Fili M., Heller D., Gasso J.A., St John M., Dharyawen R., Ragosta M., Kron I., Solenski N.J., Barrett E., Taylor A., Kramer C., Keeley E., Gimple L., Lipson L., Ong L., Hartman A., Vishnubhakat M., Klein I., Lee A., Kaplan B., Park C., Marchant D., Jauhar R., Esposito R., Kalimi R., Katz S., Green S., Shamoon F., Krause T.J., Weisbrot F., Baranetsky N., Chakhtoura E., Dailey-Sterling F., Goldstein J., Younan S., Hirsch C., Zapolanski A., Levin K., Cobin R., Agarwal A., Reison D., Strain J., Kesselbrenner M., Zelman R., Rizzo R., McCarthy J., Woudenberg-Crowell M., Farah Z., Coolong A., Leeman D., Pirundini P., Staniloae C.S., Homberg-Pinassi E., Liu M.H., Fearon W., Burdon T., Kilgore S., Kraemer F., Fann J., Giacomini J., Thai H., Rhenman B., Rapcsak S., Thomson S., Juneman E., Sethi G., Moulton M., Movahed M.R., Goldman S., Gustavo T.S., Attubato M., Babaev A., Henry K., Richardson S., Galloway A., Feit F., Slater J., Hochman J., Yatskar L., Keller N., Breall J.A., Mahomed Y., Williams L., Roach P., Sinha A., Meldrum D., von der Lohe E., Bolad I., Kourany M.J., Sadanandan S., Sharp T., Morris K.G., Ebersole D., Traviesa D., Oates T., Massaro J., Browne K., Mines M., Smith K., Hess P., Fernandez H., Kennedy L., Quinn S.L., Klodell C., Staples E., Anderson R.D., Denardo S.J., Beaver T., Palacios I., Vlahakes G.J., Buonanno F., Godine J., Akins C.W., Jaffer F.A., Jang I.K., Inglessis-Azuaje I., Rosenfield K., MacGillivray T.G., Sedlis S.P., Grossi E., Staudinger R., Danoff A., Culliford A., Lorin J., Matthai W.H., Hargrove C., Khella S., Finkel D., Moak A., Pochettino A., Frankil C.A., Chang G., Acker M., Li R.H., Groh W.C., Tanguay J.F., Cartier R., Lanthier S., Chiasson J.L., Bouchard D., Gosselin G., Jeanmart H., Ly H.Q., Crepeau J., Gregoire J.C., Perrault L.P., Carrier M., Joyal M., Pellerin M., Poirier N., Demers P., L'Allier P., Page P., de Guise P., Bonan R., Ibrahim R., Doucet S., Hebert Y., Klinke W.P., Penn A., Miller D.B., Della Siega A., Fretz E., Vuurmans J.L., Williams M.B., Mildenberger R.D., Kinloch R.D., Aymong E., Abel J., Johnston D., Gill S., Cheung A., Fung A., Wood D., Ling H., Hamburger J., Bashir J., Ye J., Webb J., Ramanathan K., Carere R., Lichtenstein S., Boone R., Gurvitch R., Simkus G., Karim S., Ho K., Priestman A., Chan A., Hayden R., Kuritzky R., Latham T., Reeves F., Normandin L., Duquette P., Lanthier S., Beauregard H., Gagnon R.M., Gobeil F., Helou J., Leclerc G., Rinfret S., Rivard A., Barbeau G., Baillot R., Bouchard R., Raby K., Noel B., Nguyen C.M., Doyle D., Larose E., Proulx G., Metras J., Dery J.P., Cabau J.R., Roy L., Bertrand O., Gleeton O., DeLarochelliere R., Cohen E.A., Fremes S., Black S., Fettes I.M., Strauss B., Ko D.T., Christakis G., Cohen G., Pang J.T., Madan M., Radhakrishnan S., Chisholm R., Latter D., Selchen D., Leiter L., Kutryk M., Lazzam C., Bhatnagar G., Selchen D., Suk A.G., Cutrara C., Puley G., Singh I., Watson R., Labinaz M., Rubens F., Giaccone R., Ooi T.C., Glover C., Lemay M., Hendry P., Masters R., Curtis M., Maitland A., Federico P., Grundy P., Anderson T., Burton J.R., Koshal A., Shuaib A., Morrish D.W., Ross D., MacArthur R., O'Neill B.J., Graham M., Ghorpade N., Muzyka T., Tymchak W., Schampaert E., Page P., Monette M.J., Hellou M., Hamel D., Palisaitis D., Diodati J., Hugues J., Doucet M., Terriault P., Demers P., Tessier P., Charron T., Choquet Y., Saucedo J., Peyton M., Lyons T.J., Exaire-Rodgriguz J.E., Hennebry T.A., Goldberg S.L., Aldea G., Becker K., Hirsh I., Stewart D., Verrier E., Dean L.S., Kostuk W., Kiaii B., Young B., Hramiak I.M., Jablonsky G., Syed J., Sridhar K., Quantz M., Diamantouros P., Teefy P., Title L., Ali I., Gubitz G., Ransom T., Hirsch G., Beydoun H., Barolet A., Rao V., Jaigobin C., Groenewoud Y., Ross J., Schwartz L., Cusimano R.J., Brister S., Yau T., Dzavik V., Velianou J.L., Lamy A., Silva J., Prebtani A., Cybulsky I., Natarajan M., Valettas N., Goldberg S., Wechsler A.S., Tabby D., Miller H., McCormack D., Entwistle J., Kussmaul W., Campos A., Miramontes J.C., Jimenez H.J., Escobedo J., Lepe L., Gencheff N.E., Baldwin D., Politi R., Jaecklein F.P., Marder C.C., Pesola D.A., Pap J.M., LeGalley T.D., Jean W.J., Garrat K., Subramanian V., Carasca 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Denktas A.E., Estrera A., Barker C., Letsou G., Anderson H.V., Fasulo M., Smalling R., Sdringola S., Stouffer G., Sheridan B., Felix A.C., Londono J.C., Lamelas J., Diaz G., Cross J., Patel A.N., Wilder M., McClain D., Naidu S., Schubach S., Wirkowski E., Sievert R., Goncalves J., Marzo K., Khouzam R., Devarapalli S., Inamdar V., Chesebro J., Harrison L., Moonis M., Malkani S., Smith C., Fisher D., Folland E., Krasnow J., Barringhaus K., Okike O.N., Wholey R., Tam S., Dib N., Dreicer V., Hodgson J., Ambrosia A., Nseir G., Ghazoul M., Kralik M., Lababidi Z., Brown D., Mack M., Nosnik P., Hollander P., Bowers B.S., Moore D., Prewitt D., Edgerton J., Parr N.G., Potluri S., Brinkman W., Ryan W., Mani A., Rosengart T., Gerber O., Narula H., Jeremias A., McLarty A., Brown D., Seifert F., Chernilas J., Gruberg L., Bilfinger T., Lawson W., Mann J.T., Landvater L., Hull K., Coxe J., Robaczewski D., Schneider J., Hook M., Sachar R., Payton R., Jobe R.L., Killinger W., Steffenino G., Agostini M., Piercarlo G.P., Gianpaolo M., Grossi C., Antonio D., Baralis G., Morena L., Colucci V., Alamgir F., Cale A., Ahmad F., Atkin S., Pfisterer M., Brett W., Lyrer P., Keller U., Kaiser C., Handke M., Buser P., Hamon M., Massetti M., Viader F., Reznik Y., Babatasi G., Grollier G., Sabatier R., Fajadet J., Soula P., Rouane J.R., Branet F., Farah B., Berthoumieu F., Marco J., Bonfils L., Sauer M., Garcia O., Dubois-Rande J.L., Loisance D., Hosseini H., Tropeano A.I., Teiger E., Kirsch M., Lesault P.F., Champagne S., Been M., Patel R., Shehu A., Randeva H.S., Glennon P., Banerjee P., Dimitri W., Frey N., Cremer J., Lindner M., Moenig H., Lins M., Wojakowski W., Bochenek A., Janas P., Fajfer D., Cisowski M., Krejca M., Macaya C., Rodriguez E., Guia J.M., Diaz A., Hernandez-Antolin R., Filgueiras C., Bestard R., Pluta W., Kaperczak J., Glaubic-Latka M., Urbanska W., Wester A., Stania K., Tomaszewski P., Kalarus Z., Zembala M., Wawrzynczyk M., Strojek K., Swiatkowski A., Pacholewicz J., Chodor 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Fernandez A., Matas C.R., Grinfeld L., Diodato L., Cesareo V., Sousa J.E., Paulista P.P., Atra M., Zatz H.P., Abizaid A., Sousa A., Feres F., Andrade G.A., Costa J.de R., Mattos L.A., Souza L.C., Tanajura L.F., Centemero M.P., Staico R., Hueb W., de Oliveira S.A., Scaff M., Wajchenberg B.L., De Gois A.F., Hueb A.C., Segre C.A., Garzillo C.L., Lima E.G., Silva E.E., Jatene F.B., Borges J.C., Ramires J.A., Dallan L.A., Perin M.A., Stolf N.A., Rezende P.C., Soares P.R., Lemos Neto P.A., Horta P.E., Garcia R.M., Mendiz O.A., Favaloro R.R., Gonzalez L.A., Matrone A.M., Gurfinkel E.P., Lev G.A., Raffaelli H.A., Abud J.A., Valdivieso L., Lernoud V.S., Noreña J.V., Orozco J.L., Borrero A.J., Arango L.G., Caramori P., Petracco J.B., de Almeida A.G., Bodanese L.C., de Barcellos C.da S., de Oliveira D.M., Goldani J.J., Goldani M.A., Lasevitch R., Gomes V.O., Belardi J., Navia D., Peralta M.C., Julio M., Candiello A., Cura F., Vrancic J.M., Lucio P., Rodriguez A., Baldi J., Cirio J.J., Calandra D., Fernandez-Pereira C., Risau G., Caviglia J., Ramon J.M., Veltri M., Ruiz M., Rodriguez M., Rubio M., Borracci R., Echeverri D., Umana J.P., Romero A., Valenzuela A., Corzo A.O., Pineda M., Damonte A., Ameriso J.L., Gomez H., Kraft M.F., Picabea E., Kozak F., Geromini H., Lasave L., Rossi M., Devlin G., Lin Z., Wright P., Wolmarans L., Sebastian C., Nunn C., Parkinson G., Kejriwal N., Ullal R., Pasupati S., Heald S., French J.K., Dignan R., MacDougall A., Depczynski B., French B., Juergens C.P., Kadappu K.K., Rajaratnam R., Lo S.T., Rankin J., Andrews D., Hankey G.J., Gan S.K., Ung K.S., Edwards M., Erickson M.F., Clugston R.A., Larbalestier R.I., Shetty S., Yeow W.L., Harding S., Mahon B., Wong E., Krebs J., Aitken A., Riordan J., Simmonds M., Matsis P., Jepson N., Grant P., Zagami A., White C., Freidman D., Pitney M., Ooi S.Y., Akhunji Z., Duffy S., Esmore D., Frayne J., Bach L., Pick A., Keighley C., Negri J., Rowland M., Marasco S., Dart T., Walton T., Sinhal A., Bennetts J., Schultz D., Stranks S., De Pasquale C., Chew D., Aylward P., Whelan A., Gilfillan I., Alvaro T., Yeap B., Hendriks R., Sharma S., Latchem D., Newman M., Blacker D., Kaye J., Wilson A., Devind B., Di Camillo C., Judkins C., Anderson H., Muhlmann M., Ammerer M.A., Walters D., Tesar P., Sandstrom P., D'Emden M., Clarke A.J., Hamilton-Craig C.R., Roper D., Poon K.K., Bett N., Chua R., Kypraios S.D., Fayers T., Wijesekera V., Elliott J., Singh H., Fink J., Scott R., Smyth D., McClean D., Richards M., Farshid A., Bissaker P., Hughes A.R., Wilson D., Jeffery I., O'Connor S.J., Bhargava B., Bisoi A.K., Goyal V., Tandon N., Roy A., Airan B., Karthikeyan G., Parakh N., Narang R., Ramakrishnan S., Seth S., Singh S., Choudhary S., Kaul U., Gupta S., Achtani R., Misra A., Gupta R.K., Bailey B., Bayfield M., Anderson C.S., Yue D.K., Adams M., Ng M.K., Harris P., Vaishnav S., Panda R., Tandel S.W., Bhoraskar A., Rath P.K., Taranath S.T., Kumar V., Khanna S.N., Reddi R., Jha S., Sethi S., Sebastian M., Mohajeri M., Gates P., Nicholson G., Zhang B., Amerena J., Yip T., Haridas K.K., Nair S.K., Kumar R.S., Unnikrishnan A.G., Prasad V.S., Natarajan K.U., Vijayakumar M., Padmanabhan M., Kamath P., Thachathodiyil R., Chandrasekharan R., Garrahy P., Peters P., Boyle R., Russell A., Cox S., Prasan A., Horton M., O'Sullivan A., Manganas C., Ramsay D., Rees D., Fermanis G., Sader M., Binnekamp M., Meredith I., Pick A., Smith J., Bower S., Teede H.J., Almeida A., Goldstein J., Antonis P., Moshinsky R.A., Ahmar W., Malaiapan Y., Rafter T., Mau T., Read S., Moore G., Keogh M., Garlick B., Cross D., Kaul U., Mishra Y.K., Dwividi S., Sharma A., Mathur A., Agarwal P., Gupta R., Kler T., Meharwal Z.S.
ISSN
1533-4406 (Electronic)
ISSN-L
0028-4793
Publication state
Published
Issued date
20/12/2012
Peer-reviewed
Oui
Volume
367
Number
25
Pages
2375-2384
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
In some randomized trials comparing revascularization strategies for patients with diabetes, coronary-artery bypass grafting (CABG) has had a better outcome than percutaneous coronary intervention (PCI). We sought to discover whether aggressive medical therapy and the use of drug-eluting stents could alter the revascularization approach for patients with diabetes and multivessel coronary artery disease.
In this randomized trial, we assigned patients with diabetes and multivessel coronary artery disease to undergo either PCI with drug-eluting stents or CABG. The patients were followed for a minimum of 2 years (median among survivors, 3.8 years). All patients were prescribed currently recommended medical therapies for the control of low-density lipoprotein cholesterol, systolic blood pressure, and glycated hemoglobin. The primary outcome measure was a composite of death from any cause, nonfatal myocardial infarction, or nonfatal stroke.
From 2005 through 2010, we enrolled 1900 patients at 140 international centers. The patients' mean age was 63.1±9.1 years, 29% were women, and 83% had three-vessel disease. The primary outcome occurred more frequently in the PCI group (P=0.005), with 5-year rates of 26.6% in the PCI group and 18.7% in the CABG group. The benefit of CABG was driven by differences in rates of both myocardial infarction (P<0.001) and death from any cause (P=0.049). Stroke was more frequent in the CABG group, with 5-year rates of 2.4% in the PCI group and 5.2% in the CABG group (P=0.03).
For patients with diabetes and advanced coronary artery disease, CABG was superior to PCI in that it significantly reduced rates of death and myocardial infarction, with a higher rate of stroke. (Funded by the National Heart, Lung, and Blood Institute and others; FREEDOM ClinicalTrials.gov number, NCT00086450.).
In this randomized trial, we assigned patients with diabetes and multivessel coronary artery disease to undergo either PCI with drug-eluting stents or CABG. The patients were followed for a minimum of 2 years (median among survivors, 3.8 years). All patients were prescribed currently recommended medical therapies for the control of low-density lipoprotein cholesterol, systolic blood pressure, and glycated hemoglobin. The primary outcome measure was a composite of death from any cause, nonfatal myocardial infarction, or nonfatal stroke.
From 2005 through 2010, we enrolled 1900 patients at 140 international centers. The patients' mean age was 63.1±9.1 years, 29% were women, and 83% had three-vessel disease. The primary outcome occurred more frequently in the PCI group (P=0.005), with 5-year rates of 26.6% in the PCI group and 18.7% in the CABG group. The benefit of CABG was driven by differences in rates of both myocardial infarction (P<0.001) and death from any cause (P=0.049). Stroke was more frequent in the CABG group, with 5-year rates of 2.4% in the PCI group and 5.2% in the CABG group (P=0.03).
For patients with diabetes and advanced coronary artery disease, CABG was superior to PCI in that it significantly reduced rates of death and myocardial infarction, with a higher rate of stroke. (Funded by the National Heart, Lung, and Blood Institute and others; FREEDOM ClinicalTrials.gov number, NCT00086450.).
Keywords
Aged, Angioplasty, Balloon, Coronary, Cardiovascular Diseases/mortality, Coronary Artery Bypass, Coronary Artery Disease/complications, Coronary Artery Disease/surgery, Coronary Artery Disease/therapy, Diabetes Complications/surgery, Diabetes Complications/therapy, Drug-Eluting Stents, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Myocardial Infarction/epidemiology, Stroke/epidemiology
Pubmed
Web of science
Open Access
Yes
Create date
28/03/2019 18:51
Last modification date
14/05/2024 9:00