Hepatitis B Virus e Antigen Physically Associates With Receptor-Interacting Serine/Threonine Protein Kinase 2 and Regulates IL-6 Gene Expression.

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Serval ID
serval:BIB_98603AB7AD12
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatitis B Virus e Antigen Physically Associates With Receptor-Interacting Serine/Threonine Protein Kinase 2 and Regulates IL-6 Gene Expression.
Journal
Journal of Infectious Diseases
Author(s)
Wu S., Kanda T., Imazeki F., Nakamoto S., Tanaka T., Arai M., Roger T., Shirasawa H., Nomura F., Yokosuka O.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
Published
Issued date
2012
Volume
206
Number
3
Pages
415-420
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
We previously reported that hepatitis B virus (HBV) e antigen (HBeAg) inhibits production of interleukin 6 by suppressing NF-κB activation. NF-κB is known to be activated through receptor-interacting serine/threonine protein kinase 2 (RIPK2), and we examined the mechanisms of interleukin 6 regulation by HBeAg. HBeAg inhibits RIPK2 expression and interacts with RIPK2, which may represent 2 mechanisms through which HBeAg blocks nucleotide-binding oligomerization domain-containing protein 1 ligand-induced NF-κB activation in HepG2 cells. Our findings identified novel molecular mechanisms whereby HBeAg modulates intracellular signaling pathways by targeting RIPK2, supporting the concept that HBeAg could impair both innate and adaptive immune responses to promote chronic HBV infection.
Pubmed
Web of science
Open Access
Yes
Create date
18/08/2012 10:58
Last modification date
25/09/2019 7:10
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