Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey.

Details

Serval ID
serval:BIB_9843A972CEC8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey.
Journal
The Journal of clinical endocrinology and metabolism
Author(s)
Vulliémoz N.R., Xiao E., Xia-Zhang L., Germond M., Rivier J., Ferin M.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Publication state
Published
Issued date
11/2004
Peer-reviewed
Oui
Volume
89
Number
11
Pages
5718-5723
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
Ghrelin, a nutrition-related peptide secreted by the stomach, is elevated during prolonged food deprivation. Because undernutrition is often associated with a suppressed reproductive axis, we have postulated that increasing peripheral ghrelin levels will decrease the activity of the GnRH pulse generator. Adult ovariectomized rhesus monkeys (n = 6) were subjected to a 5-h iv human ghrelin (100- to 150-microg bolus followed by 100-150 microg/h) or saline infusion, preceded by a 3-h saline infusion to establish baseline pulsatile LH release. Blood samples were collected at 15-min intervals throughout the experiment. Ghrelin infusion increased plasma ghrelin levels 2.9-fold of baseline. Ghrelin significantly decreased LH pulse frequency (from 0.89 +/- 0.07/h in baseline to 0.57 +/- 0.10/h during ghrelin infusion; P < 0.05, mean +/- sem), whereas LH pulse frequency remained unchanged during saline treatment. LH pulse amplitude was not affected. Ghrelin also significantly stimulated both cortisol and GH release, but had no effect on leptin. We conclude that ghrelin can inhibit GnRH pulse activity and may thereby mediate the suppression of the reproductive system observed in conditions of undernutrition, such as in anorexia nervosa. Ghrelin also activates the adrenal axis, but the relevance of this to the inhibition of GnRH pulse frequency remains to be established.
Keywords
Agouti-Related Protein, Animals, Female, Ghrelin, Hypothalamo-Hypophyseal System/drug effects, Intercellular Signaling Peptides and Proteins, Luteinizing Hormone/blood, Macaca mulatta, Neuropeptide Y/biosynthesis, Ovariectomy, Peptide Hormones/pharmacology, Pituitary-Adrenal System/drug effects, Proteins/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
02/10/2019 19:38
Last modification date
08/10/2019 5:26
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