Neural detection of complex sound sequences in the absence of consciousness.

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Serval ID
serval:BIB_983B0B3505D6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neural detection of complex sound sequences in the absence of consciousness.
Journal
Brain
Author(s)
Tzovara A., Simonin A., Oddo M., Rossetti A.O., De Lucia M.
ISSN
1460-2156 (Electronic)
ISSN-L
0006-8950
Publication state
Published
Issued date
2015
Volume
138
Number
Pt 5
Pages
1160-1166
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
The neural response to a violation of sequences of identical sounds is a typical example of the brain's sensitivity to auditory regularities. Previous literature interprets this effect as a pre-attentive and unconscious processing of sensory stimuli. By contrast, a violation to auditory global regularities, i.e. based on repeating groups of sounds, is typically detectable when subjects can consciously perceive them. Here, we challenge the notion that global detection implies consciousness by testing the neural response to global violations in a group of 24 patients with post-anoxic coma (three females, age range 45-87 years), treated with mild therapeutic hypothermia and sedation. By applying a decoding analysis to electroencephalographic responses to standard versus deviant sound sequences, we found above-chance decoding performance in 10 of 24 patients (Wilcoxon signed-rank test, P < 0.001), despite five of them being mildly hypothermic, sedated and unarousable. Furthermore, consistently with previous findings based on the mismatch negativity the progression of this decoding performance was informative of patients' chances of awakening (78% predictive of awakening). Our results show for the first time that detection of global regularities at neural level exists despite a deeply unconscious state.
Pubmed
Web of science
Open Access
Yes
Create date
22/05/2015 17:41
Last modification date
25/09/2019 7:10
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