Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_981C6361FEC4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice.
Journal
Nutrients
Author(s)
Yzydorczyk C., Li N., Rigal E., Chehade H., Mosig D., Armengaud J.B., Rolle T., Krishnasamy A., Orozco E., Siddeek B., Juvet C., Vergely C., Simeoni U.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Publication state
Published
Issued date
16/11/2019
Peer-reviewed
Oui
Volume
11
Number
11
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) in mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this study, we investigated whether such changes can be reversed by moderate calorie restriction (CR). C57BL/6 male mice pups were maintained during lactation in litters adjusted to nine pups in the normal feeding (NF) group and three pups in the transient postnatal OF group. At six months of age, adult mice from the NF and OF groups were randomly assigned to an ad libitum diet or CR (daily energy supply reduced by 20%) for one month. In each group, at the age of seven months, analysis of liver structure, liver markers of OS (superoxide anion, antioxidant defenses), and SIPS (lipofuscin, p53, p21, p16, pRb/Rb, Acp53, sirtuin-1) were performed. CR in the OF group reduced microsteatosis, decreased levels of superoxide anion, and increased protein expression of catalase and superoxide dismutase. Moreover, CR decreased lipofuscin staining, p21, p53, Acp53, and p16 but increased pRb/Rb and sirtuin-1 protein expression. CR did not affect the NF group. These results suggest that CR reduces hepatic disorders induced by OF.
Keywords
Animals, Animals, Newborn, Caloric Restriction/methods, Catalase/metabolism, Cellular Senescence, Feeding Methods/adverse effects, Female, Liver/metabolism, Liver Diseases/diet therapy, Liver Diseases/etiology, Liver Diseases/physiopathology, Male, Mice, Mice, Inbred C57BL, Oxidative Stress, Superoxide Dismutase/metabolism, DOHaD, developmental programming, liver, oxidative stress, reversibility, stress-induced premature senescence
Pubmed
Web of science
Open Access
Yes
Create date
21/11/2019 16:45
Last modification date
29/07/2020 6:22
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