The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction-Victim of Its Environment?

Details

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_98080A5141E0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction-Victim of Its Environment?
Journal
Cells
Author(s)
Rocca A., van Heeswijk R.B., Richiardi J., Meyer P., Hullin R.
ISSN
2073-4409 (Electronic)
ISSN-L
2073-4409
Publication state
Published
Issued date
02/03/2022
Peer-reviewed
Oui
Volume
11
Number
5
Pages
867
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Heart failure (HF) with preserved left ventricular ejection fraction (HFpEF) is becoming the predominant form of HF. However, medical therapy that improves cardiovascular outcome in HF patients with almost normal and normal systolic left ventricular function, but diastolic dysfunction is missing. The cause of this unmet need is incomplete understanding of HFpEF pathophysiology, the heterogeneity of the patient population, and poor matching of therapeutic mechanisms and primary pathophysiological processes. Recently, animal models improved understanding of the pathophysiological role of highly prevalent and often concomitantly presenting comorbidity in HFpEF patients. Evidence from these animal models provide first insight into cellular pathophysiology not considered so far in HFpEF disease, promising that improved understanding may provide new therapeutical targets. This review merges observation from animal models and human HFpEF disease with the intention to converge cardiomyocytes pathophysiological aspects and clinical knowledge.
Keywords
animal models, cardiomyocyte, heart failure with preserved left ventricular ejection fraction
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / CRSII5_202276
Create date
21/03/2022 10:24
Last modification date
06/05/2022 6:34
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