Aspirin and statin use and the subsequent development of depression in men and women: Results from a longitudinal population-based study.

Details

Ressource 1Download: 25985382.pdf (938.50 [Ko])
State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_98069CD14FF9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Aspirin and statin use and the subsequent development of depression in men and women: Results from a longitudinal population-based study.
Journal
Journal of Affective Disorders
Author(s)
Glaus J., Vandeleur C.L., Lasserre A.M., Strippoli M.P., Castelao E., Gholam-Rezaee M., Waeber G., Aubry J.M., Vollenweider P., Preisig M.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
182
Pages
126-131
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
OBJECTIVE: Low-grade chronic inflammation is one potential mechanism underlying the well-established association between major depressive disorder (MDD) and increased cardiovascular morbidity. Both aspirin and statins have anti-inflammatory properties, which may contribute to their preventive effect on cardiovascular diseases. Previous studies on the potentially preventive effect of these drugs on depression have provided inconsistent results. The aim of the present paper was to assess the prospective association between regular aspirin or statin use and the incidence of MDD.
METHOD: This prospective cohort study included 1631 subjects (43.6% women, mean age 51.7 years), randomly selected from the general population of an urban area. Subjects underwent a thorough physical evaluation as well as semi-structured interviews investigating DSM-IV mental disorders at baseline and follow-up (mean duration 5.2 years). Analyses were adjusted for a wide array of potential confounders.
RESULTS: Our main finding was that regular aspirin or statin use at baseline did not reduce the incidence of MDD during follow-up, regardless of sex or age (hazard ratios, aspirin: 1.19; 95%CI, 0.68-2.08; and statins: 1.25; 95%CI, 0.73-2.14; respectively).
LIMITATIONS: Our study is not a randomized clinical trial and could not adjust for all potential confounding factors, information on aspirin or statin use was collected only for the 6 months prior to the evaluations, and the sample was restricted to subjects between 35 and 66 years of age.
CONCLUSION: Our data do not support a large scale preventive treatment of depression using aspirin or statins in subjects aged from 35 to 66 years from the community.
Pubmed
Web of science
Create date
26/05/2015 9:03
Last modification date
27/09/2019 8:58
Usage data