Nitric oxide release accounts for insulin's vascular effects in humans
Details
Serval ID
serval:BIB_98053A7606E1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nitric oxide release accounts for insulin's vascular effects in humans
Journal
Journal of Clinical Investigation
ISSN
0021-9738 (Print)
Publication state
Published
Issued date
12/1994
Volume
94
Number
6
Pages
2511-5
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
Insulin exerts effects on the vasculature that (a) may play a role in the regulation of blood pressure; and (b) by boosting its own delivery to target tissues, also have been proposed to play an integral part in its main action, the promotion of glucose disposal. To study the role of nitric oxide (NO) in the mediation of insulin's effects on the peripheral vasculature, NG-monomethyl-L-arginine (L-NMMA), a specific inhibitor of the synthesis of endothelium-derived NO, was infused into the brachial arteries of healthy volunteers both before, and at the end of a 2-h hyperinsulinemic (6 pmol/kg per min) euglycemic clamp. L-NMMA (but not norepinephrine, an NO-independent vasoconstrictor) caused larger reductions in forearm blood flow during hyperinsulinemia than at baseline. Moreover, L-NMMA prevented insulin-induced vasodilation throughout the clamp. Prevention of vasodilation by L-NMMA led to significant increases in arterial pressure during insulin/glucose infusion but did not alter glucose uptake. These findings indicate that insulin's vasodilatory effects are mediated by stimulation of NO release, and that they play a role in the regulation of arterial pressure during physiologic hyperinsulinemia. Abnormalities in insulin-induced NO release could contribute to altered vascular function and hypertension in insulin-resistant states.
Keywords
Acetylcholine/pharmacology
Adult
Arginine/analogs & derivatives/pharmacology
Brachial Artery
Calorimetry, Indirect
Forearm
Glucose/*metabolism
Glucose Clamp Technique
Humans
Infusions, Intra-Arterial
Insulin/*pharmacology
Male
Nitric Oxide/*metabolism
Nitroprusside/pharmacology
Norepinephrine/pharmacology
Regional Blood Flow/*drug effects
Vascular Resistance/drug effects
Vasodilation/*drug effects
omega-N-Methylarginine
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:00
Last modification date
20/08/2019 15:59