Hyperréactivité de l'artère humérale à la noradrénaline chez l'hypertendu essentiel [Hyperreactivity of the humeral artery to noradrenaline in essential hypertension patients]

Details

Serval ID
serval:BIB_979DFFBC96F5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Hyperréactivité de l'artère humérale à la noradrénaline chez l'hypertendu essentiel [Hyperreactivity of the humeral artery to noradrenaline in essential hypertension patients]
Journal
Archives des Maladies du Coeur et des Vaisseaux
Author(s)
Laurent S., Juillerat L., London G., Nussberger J., Brunner H., Safar M.
ISSN
0003-9683
Publication state
Published
Issued date
06/1987
Peer-reviewed
Oui
Volume
80
Number
6
Pages
826-831
Language
french
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial
Abstract
The hyperresponsiveness of small arteries to norepinephrine is well documented in essential hypertensive patients. Our objective was to investigate in situ the reactivity to norepinephrine of the diameter of large arteries which are involved in the arterial disease of hypertension as well as small arteries. Brachial artery diameter, blood flow velocity, local volumic blood flow and local vascular resistances were determined non invasively using a pulsed Doppler system in 19 patients with essential hypertension and 9 normotensive subjects, before and after placebo (glucose) or increasing doses of norepinephrine (10, 20 and 40 ng/kg/min; i.v.) given in a single blind fashion. In hypertensive patients, norepinephrine (40 ng/kg/min) induced (i) a significant decrease in brachial artery diameter, local blood velocity, volumic flow and conductance and (ii) a small increase in mean arterial pressure. These hemodynamic changes did not occurred in the placebo group and were significantly greater in hypertensive patients than in normotensive subjects although plasma norepinephrine increased to the same extent in both groups. We conclude that in hypertensive patients, the increase in vascular reactivity to norepinephrine involves not only the resistive vessels, but also the large arteries thus decreasing their conducting and buffering function.
Keywords
Adult, Arteries/drug effects, Blood Flow Velocity, Female, Humans, Humerus/blood supply, Hypertension/blood, Hypertension/physiopathology, Male, Middle Aged, Norepinephrine/blood, Norepinephrine/pharmacology, Vascular Resistance
Pubmed
Web of science
Create date
05/03/2008 17:41
Last modification date
20/08/2019 15:59
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