Extensive linkage disequilibrium in small human populations in Eurasia.
Details
Serval ID
serval:BIB_9766191B1E81
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Extensive linkage disequilibrium in small human populations in Eurasia.
Journal
American Journal of Human Genetics
ISSN
0002-9297 (Print)
ISSN-L
0002-9297
Publication state
Published
Issued date
2002
Volume
70
Number
3
Pages
673-685
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The extent of linkage disequilibrium (LD) was studied in two small food-gathering populations-Evenki and Saami-and two larger food-producing populations-Finns and Swedes-in northern Eurasia. In total, 50 single-nucleotide polymorphisms (SNPs) from five genes were genotyped using real-time pyrophosphate DNA sequencing, whereas 14 microsatellites were genotyped in two X-chromosomal regions. In addition, hypervariable region I of the mtDNA was sequenced to shed light on the demographic history of the populations. The SNP data, as well as the microsatellite data, reveal extensive levels of LD in Evenki and Saami when compared to Finns and Swedes. mtDNA-sequence variation is compatible with constant population size over time in Evenki and Saami but indicates population expansion in Finns and Swedes. Furthermore, the similarity between Finns and Swedes in SNP allele- and haplotype-frequency distributions indicate that these two populations may share a recent common origin. These findings suggest that populations such as the Evenki and the Saami, rather than the Finns, may be particularly suited for the initial coarse mapping of common complex diseases.
Keywords
Chromosome Mapping/methods, DNA, Mitochondrial/genetics, Finland, Food Supply, Gene Frequency, Genetic Variation/genetics, Genotype, Globins/genetics, Haplotypes/genetics, Humans, Linkage Disequilibrium/genetics, Lipoprotein Lipase/genetics, Microsatellite Repeats/genetics, Molecular Sequence Data, Peptidyl-Dipeptidase A/genetics, Polymorphism, Single Nucleotide/genetics, Sample Size, Siberia, Sweden, X Chromosome/genetics
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:41
Last modification date
20/08/2019 15:59