Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates.

Details

Serval ID
serval:BIB_9748
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Urinary NAG and GAG as biomarkers of renal effects in exposure to 2-alkoxyalcohols and their acetates.
Journal
Journal of Occupational and Environmental Hygiene
Author(s)
Laitinen J., Liesivuori J., Savolainen H.
ISSN
1076-2752
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
40
Number
7
Pages
595-600
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Abstract
Many sensitive biomarkers are available for the surveillance of the early health effects of chemicals on humans. This study was conducted to evaluate the usefulness of glycosaminoglycans (GAG) as biomarkers of early kidney effects in exposure to 2-alkoxyethanols and their acetates. GAG were compared with effects on the urinary beta-N-acetylglycosaminidase activity (NAG). According to the results of the present study, the excretion rate of GAG was higher among women than men. On the other hand, the excretion rate of GAG was lower among exposed subjects than among the controls, and the level was decreased at the tested levels of exposure. The NAG activity was higher in most of the exposed groups than in the controls. The data indicated that an appropriate urinary limit value for ethoxyacetic acid was 30 mmol/mol creatinine in postshift samples and that this value corresponded to an 8-hour exposure level of 2 cm3/m3 2-ethoxyethylacetate. Urinary butoxyacetic acid excretion of 60 mmol/mol creatinine corresponded to the inhalation exposure level of 5 cm3/m3 2-butoxyethanol and its acetate in postshift samples.
Keywords
Acetates, Adult, Alcohols, Analysis of Variance, Biological Markers, Environmental Monitoring, Female, Glycosaminoglycans, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Occupational Exposure, Phosphotransferases (Alcohol Group Acceptor), Sensitivity and Specificity, Solvents, Urine
Pubmed
Web of science
Create date
19/11/2007 12:48
Last modification date
20/08/2019 14:59
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