Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_97468B91FF8C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length.
Journal
Journal of clinical sleep medicine
Author(s)
Tempaku P., Hirotsu C., Mazzotti D., Xavier G., Maurya P., Brietzke E., Belangero S., Poyares D., Bittencourt L., Tufik S.
ISSN
1550-9397 (Electronic)
ISSN-L
1550-9389
Publication state
Published
Issued date
15/12/2018
Peer-reviewed
Oui
Volume
14
Number
12
Pages
2037-2045
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample.
As part of the EPISONO cohort (São Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment, and had peripheral blood collected for DNA extraction. Insomnia was diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition; and obstructive sleep apnea was defined according to apnea-hypopnea index. For the objective insomnia phenotype, we combined insomnia diagnosis with total sleep time from polysomnography with a cutoff of 360 minutes, allowing the classification of six groups. Self-reported sleep duration was used to classify the individuals as short (< 6 hours), average (6 to 8 hours) and long (> 8 hours) sleepers. The leukocyte telomere length was measured using quantitative real-time polymerase chain reaction. Based on its distribution, we considered leukocyte telomere length < 10th percentile as short telomere and leukocyte telomere length ≥ 10th percentile as non-short telomere.
After adjusting for sex, age, and body mass index, only insomnia disorder (odds ratio [OR] = 2.654, 95% confidence interval [CI] = 1.025-6.873, P = .044), insomnia disorder total sleep time < 360 minutes (OR = 4.205, 95% CI = 1.097-16.117, P = .036) and long sleepers (OR = 2.177, 95% CI = 1.189- 3.987, P = .012) were associated with short telomere.
Our findings support the existence of an association among insomnia, insomnia phenotype, and self-reported long sleep duration with the maintenance of telomere length.
A commentary on this article appears in this issue on page 1975.
Keywords
Adult, Aged, Correlation of Data, Female, Humans, Male, Middle Aged, Polysomnography, Sleep/physiology, Sleep Initiation and Maintenance Disorders/physiopathology, Surveys and Questionnaires, Telomere Shortening/physiology, Time Factors, insomnia, long sleep duration, sleep, telomeres
Pubmed
Web of science
Open Access
Yes
Create date
18/12/2019 14:11
Last modification date
04/08/2020 10:46
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