Epithelial sodium channel, salt intake, and hypertension.

Details

Serval ID
serval:BIB_973A1AAB774F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Epithelial sodium channel, salt intake, and hypertension.
Journal
Current Hypertension Reports
Author(s)
Hummler E.
ISSN
1522-6417 (Print)
ISSN-L
1522-6417
Publication state
Published
Issued date
02/2003
Peer-reviewed
Oui
Volume
5
Number
1
Pages
11-18
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The epithelial sodium channel (ENaC) is a membrane protein made of three different but homologous subunits (a, b, and g) present in the apical membrane of epithelial cells of, for example, the distal nephron. This channel is responsible for salt reabsorption in the kidney and can cause human diseases by increasing channel function in Liddle's syndrome, a form of hereditary hypertension, or by decreasing channel function in pseudohypoaldosteronism type I, a salt-wasting disease in infancy. This review briefly discusses recent advances in understanding the implication of ENaC in Liddle's syndrome and in pseudohypoaldosteronism type I, both caused by mutations in the SCNN1 (ENaC) genes. Furthermore, it is still an open question to which extent SCNN1 genes coding for ENaC might be implicated in essential hypertension. The development of Scnn1 genetically engineered mouse models will provide the opportunity to test the effect of environmental factors, like salt intake, on the development of this kind of salt- sensitive hypertension.
Keywords
Animals, Disease Models, Animal, Epithelial Sodium Channels, Humans, Hypertension/genetics, Hypertension/physiopathology, Mice, Mutation, Potassium/metabolism, Pseudohypoaldosteronism/genetics, Pseudohypoaldosteronism/physiopathology, Rats, Sodium/metabolism, Sodium Channels/genetics, Sodium Channels/physiology, Sodium, Dietary/administration & dosage, Sodium, Dietary/adverse effects, Syndrome
Pubmed
Web of science
Create date
24/01/2008 12:43
Last modification date
20/08/2019 14:59
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