Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms.

Details

Serval ID
serval:BIB_971182A4A822
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms.
Journal
Communications biology
Author(s)
Brechbühl J., Lopes A.C., Wood D., Bouteiller S., de Vallière A., Verdumo C., Broillet M.C.
ISSN
2399-3642 (Electronic)
ISSN-L
2399-3642
Publication state
Published
Issued date
15/07/2021
Peer-reviewed
Oui
Volume
4
Number
1
Pages
880
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
COVID-19 pandemic has given rise to a collective scientific effort to study its viral causing agent SARS-CoV-2. Research is focusing in particular on its infection mechanisms and on the associated-disease symptoms. Interestingly, this environmental pathogen directly affects the human chemosensory systems leading to anosmia and ageusia. Evidence for the presence of the cellular entry sites of the virus, the ACE2/TMPRSS2 proteins, has been reported in non-chemosensory cells in the rodent's nose and mouth, missing a direct correlation between the symptoms reported in patients and the observed direct viral infection in human sensory cells. Here, mapping the gene and protein expression of ACE2/TMPRSS2 in the mouse olfactory and gustatory cells, we precisely identify the virus target cells to be of basal and sensory origin and reveal the age-dependent appearance of viral entry-sites. Our results propose an alternative interpretation of the human viral-induced sensory symptoms and give investigative perspectives on animal models.
Keywords
Age Factors, Ageusia/physiopathology, Ageusia/virology, Animals, Anosmia/physiopathology, Anosmia/virology, COVID-19/physiopathology, COVID-19/virology, Female, Male, Mice, Olfactory Perception, SARS-CoV-2/physiology, Taste Perception
Pubmed
Web of science
Open Access
Yes
Create date
26/07/2021 10:42
Last modification date
25/02/2022 7:37
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