Efficacy of Antifungal Monotherapies and Combinations against Aspergillus calidoustus.

Details

Serval ID
serval:BIB_96BD38D42E6D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Efficacy of Antifungal Monotherapies and Combinations against Aspergillus calidoustus.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Glampedakis E. (co-first), Coste A.T. (co-first), Aruanno M., Bachmann D., Delarze E., Erard V., Lamoth F.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
62
Number
12
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Invasive fungal infections due to Aspergillus calidoustus with decreased azole susceptibility are emerging in the setting of azole prophylaxis and are associated with poor outcomes. We assessed the in vitro activity of antifungal drugs used alone or in combinations against A. calidoustus and found a synergistic effect between voriconazole and terbinafine at concentrations within the therapeutic range. An invertebrate Galleria mellonella model of A. calidoustus infection tended to support the potential benefit of this combination.
Keywords
Animals, Antifungal Agents/pharmacology, Antifungal Agents/therapeutic use, Aspergillosis/drug therapy, Aspergillus/drug effects, Aspergillus/isolation & purification, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Humans, Microbial Sensitivity Tests, Moths, Terbinafine/therapeutic use, Voriconazole/therapeutic use, Aspergillus ustus, Galleria mellonella, Usti, amphotericin B, invasive fungal infections, synergism, terbinafine, voriconazole
Pubmed
Web of science
Create date
30/10/2018 13:01
Last modification date
28/01/2021 7:25
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