Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells

Details

Serval ID
serval:BIB_96B8EFD00345
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Shear stress and cyclic circumferential stretch, but not pressure, alter connexin43 expression in endothelial cells
Journal
Cell Communication and Adhesion
Author(s)
Kwak  B. R., Silacci  P., Stergiopulos  N., Hayoz  D., Meda  P.
ISSN
1541-9061 (Print)
Publication state
Published
Issued date
12/2005
Volume
12
Number
5-6
Pages
261-70
Notes
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't --- Old month value: Jul-Dec
Abstract
Hemodynamic forces play a critical role in atherogenesis, as evidenced by the focal pattern of development of atherosclerotic lesions. Whereas disturbed flow in the branches and curved regions of large arteries is proatherogenic, laminar flow in the straight parts of vessels is atheroprotective. In addition, hypertension and age-related changes in arterial stiffness are important risk factors of the disease. Hemodynamic forces induce various changes in the structure and function of vascular endothelium, many of which reflect alterations in gene expression. Endothelial cells are linked by gap junctions, which facilitate the propagation of electrical and chemical signals along the vascular wall. Using an in vitro perfusion system, we investigated the effects of pulsed unidirectional and oscillatory flows in combination with different levels of hydrostatic pressure and circumferential stretch on the expression of Cx43 in endothelial cells. Our results show that shear stress and circumferential stretch, but not pressure, modulate the expression of Cx43. In view of the distribution of this protein along the vascular tree, our findings provide new insights into the role of mechanical forces on gap junctional communication in regions prone to the development of atherosclerosis.
Keywords
Animals Atherosclerosis Cell Communication Cell Line, Transformed Connexin 43/biosynthesis/*metabolism Endothelial Cells/*metabolism Gap Junctions/metabolism Hydrostatic Pressure Mice Perfusion/methods Pulsatile Flow Stress, Mechanical Time Factors
Pubmed
Web of science
Create date
17/01/2008 17:38
Last modification date
20/08/2019 15:58
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