Current and evolving therapies for hepatitis C

Details

Serval ID
serval:BIB_968C82FC8236
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Current and evolving therapies for hepatitis C
Journal
European Journal of Gastroenterology and Hepatology
Author(s)
Moradpour  D., Blum  H. E.
ISSN
0954-691X (Print)
Publication state
Published
Issued date
11/1999
Volume
11
Number
11
Pages
1199-202
Notes
Journal Article
Review --- Old month value: Nov
Abstract
Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Therapeutic options for hepatitis C are limited. Standard monotherapy with interferon-alpha leads to a sustained response in only 10-20% of patients. Recent studies have shown improved sustained response rates for the combination of interferon-alpha and ribavirin. Despite these improvements, more effective therapies are needed. A variety of alternative agents are currently being evaluated in clinical trials. Recent advances in the molecular virology of hepatitis C have identified specific antiviral targets such as the viral NS3 serine protease, the RNA helicase, and the RNA-dependent RNA polymerase. In addition, gene therapeutic strategies aimed at inhibiting HCV gene expression and replication as well as immunotherapeutic concepts aimed at enhancing the cellular immune response against HCV are being explored in various experimental systems. These and other novel antiviral strategies may complement the existing therapeutic modalities in the future.
Keywords
Adjuvants, Immunologic/therapeutic use Antioxidants/therapeutic use Antiviral Agents/*therapeutic use Drug Therapy, Combination Enzyme Inhibitors/therapeutic use Hepacivirus/enzymology/genetics/immunology Hepatitis C/drug therapy/immunology/*therapy/virology Humans Interferon-alpha/therapeutic use Multicenter Studies Randomized Controlled Trials Ribavirin/therapeutic use Vaccines/therapeutic use
Pubmed
Web of science
Create date
25/01/2008 16:05
Last modification date
20/08/2019 14:58
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