Cobalamin deficiency resulting in a rare haematological disorder: a case report.

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serval:BIB_96805407B422
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cobalamin deficiency resulting in a rare haematological disorder: a case report.
Journal
Journal of Medical Case Reports
Author(s)
Chapuis T.M., Favrat B., Bodenmann P.
ISSN
1752-1947[electronic], 1752-1947[linking]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
3
Pages
80
Language
english
Notes
Publication types: Journal Article
Abstract
INTRODUCTION: We present the case of a patient with a cobalamin deficiency resulting in pancytopaenia, emphasizing the importance to define, diagnose and treat cobalamin deficiency. CASE PRESENTATION: A 52-year-old man from the Democratic Republic of Congo presented to the emergency department with shortness of breath and a sore tongue. Physical examination was unremarkable. His haemoglobin was low and the peripheral blood smear revealed pancytopaenia with a thrombotic microangiopathy. The findings were low cobalamin and folate levels, and high homocysteine and methylmalonate levels. Pernicious anaemia with chronic atrophic gastritis was confirmed by gastric biopsy and positive antiparietal cell and anti-intrinsic factor antibodies. Cobalamin with added folate was given. Six months later, the patient was asymptomatic. CONCLUSION: Cobalamin deficiency should always be ruled out in a patient with pancytopaenia. Our case report highlights a life-threatening cobalamin deficiency completely reversible after treatment.
Pubmed
Open Access
Yes
Create date
29/01/2010 14:58
Last modification date
20/08/2019 14:58
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