Whole tumor antigen vaccines.

Details

Serval ID
serval:BIB_967F0FA0867E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Whole tumor antigen vaccines.
Journal
Seminars in Immunology
Author(s)
Chiang C.L., Benencia F., Coukos G.
ISSN
1096-3618 (Electronic)
ISSN-L
1044-5323
Publication state
Published
Issued date
2010
Volume
22
Number
3
Pages
132-143
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; ReviewPublication Status: ppublish
Abstract
Although cancer vaccines with defined antigens are commonly used, the use of whole tumor cell preparations in tumor immunotherapy is a very promising approach and can obviate some important limitations in vaccine development. Whole tumor cells are a good source of TAAs and can induce simultaneous CTLs and CD4(+) T helper cell activation. We review current approaches to prepare whole tumor cell vaccines, including traditional methods of freeze-thaw lysates, tumor cells treated with ultraviolet irradiation, and RNA electroporation, along with more recent methods to increase tumor cell immunogenicity with HOCl oxidation or infection with replication-incompetent herpes simplex virus.
Keywords
Animals, Antigens, Neoplasm/immunology, Apoptosis, Cancer Vaccines/immunology, Dendritic Cells/cytology, Female, Humans, Immunotherapy/methods, Mice, Necrosis, Ovarian Neoplasms/immunology, Ovarian Neoplasms/therapy, Simplexvirus/immunology
Pubmed
Web of science
Create date
14/10/2014 11:43
Last modification date
20/08/2019 14:58
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