A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease.

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State: Public
Version: author
Serval ID
serval:BIB_967B6E43B64D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease.
Journal
Ageing Research Reviews
Author(s)
Savioz A., Leuba G., Vallet P.G.
ISSN
1872-9649 (Electronic)
ISSN-L
1568-1637
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
18
Pages
86-94
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The postsynaptic density protein PSD-95 is a major element of synapses. PSD-95 is involved in aging, Alzheimer's disease (AD) and numerous psychiatric disorders. However, contradictory data about PSD-95 expression in aging and AD have been reported. Indeed in AD versus control brains PSD-95 varies according to regions, increasing in the frontal cortex, at least in a primary stage, and decreasing in the temporal cortex. In contrast, in transgenic mouse models of aging and AD PSD-95 expression is decreased, in behaviorally aged impaired versus unimpaired rodents it can decrease or increase and finally, it is increased in rodents grown in enriched environments. Different factors explain these contradictory results in both animals and humans, among others concomitant psychiatric endophenotypes, such as depression. The possible involvement of PSD-95 in reactive and/or compensatory mechanisms during AD progression is underscored, at least before the occurrence of important synaptic elimination. Thus, in AD but not in AD transgenic mice, enhanced expression might precede the diminution commonly observed in advanced aging. A two-compartments cell model, separating events taking place in cell bodies and synapses, is presented. Overall these data suggest that AD research will progress by untangling pathological from protective events, a prerequisite for effective therapeutic strategies.
Pubmed
Web of science
Create date
16/02/2015 11:05
Last modification date
20/08/2019 14:58
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