Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets.

Details

Serval ID
serval:BIB_966C0C4FCBD9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets.
Journal
BioMed research international
Author(s)
Saulite I., Hoetzenecker W., Weidinger S., Cozzio A., Guenova E. (co-last), Wehkamp U.
ISSN
2314-6141 (Electronic)
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
2016
Pages
9717530
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.
Keywords
Cytokines/blood, Dermatitis, Atopic/blood, Dermatitis, Atopic/immunology, Dermatitis, Atopic/pathology, Dermatitis, Atopic/therapy, Humans, Immunoglobulin E/blood, Lymphoma, T-Cell, Cutaneous/blood, Lymphoma, T-Cell, Cutaneous/immunology, Lymphoma, T-Cell, Cutaneous/pathology, Lymphoma, T-Cell, Cutaneous/therapy, Sezary Syndrome/blood, Sezary Syndrome/immunology, Sezary Syndrome/pathology, Sezary Syndrome/therapy, Th2 Cells/immunology, Th2 Cells/pathology
Pubmed
Web of science
Open Access
Yes
Create date
27/08/2020 13:59
Last modification date
27/10/2020 21:11
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