Regulation of hepatic glucose production in healthy subjects and patients with non-insulin-dependent diabetes mellitus.

Details

Serval ID
serval:BIB_965A468E1CC7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Regulation of hepatic glucose production in healthy subjects and patients with non-insulin-dependent diabetes mellitus.
Journal
Diabète et Métabolisme
Author(s)
Tappy L.
ISSN
0338-1684
Publication state
Published
Issued date
06/1995
Peer-reviewed
Oui
Volume
21
Number
4
Pages
233-240
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
The regulation of endogenous glucose production is central to the control of blood glucose concentrations. In non-insulin-dependent diabetes mellitus (NIDDM), increased endogenous glucose production contributes to fasting hyperglycaemia. Gluconeogenesis appears to be exaggerated in NIDDM, and it may be hypothesized that an enhanced release of gluconeogenic precursors is responsible for increased total glucose output. However, it would appear that substrate-induced stimulation of gluconeogenesis fails to increase total glucose production in healthy humans and NIDDM patients. This autoregulation of endogenous glucose production may be attained by inhibition of glycogenolysis and/or gluconeogenesis from endogenous substrate. It has also been observed that stimulation of intrahepatic disposal of neoformed glucose (mainly as glycogen synthesis) contributes to autoregulation. These observations support the concept that intrahepatic disposal of glucose-6-phosphate plays a major role in the control of endogenous glucose production.
Keywords
Diabetes Mellitus, Type 2/metabolism, Gluconeogenesis, Glucose/biosynthesis, Glucose/metabolism, Homeostasis, Humans, Liver/metabolism, Liver Glycogen/metabolism, Reference Values
Pubmed
Web of science
Create date
03/03/2008 15:15
Last modification date
20/08/2019 14:58
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