Chorioretinitis induced by intravesical Bacillus Calmette-Guerin (BCG) instillations for urinary bladder carcinoma

Details

Serval ID
serval:BIB_9644D2EF6412
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Chorioretinitis induced by intravesical Bacillus Calmette-Guerin (BCG) instillations for urinary bladder carcinoma
Journal
Klinische Monatsblatter fur Augenheilkunde
Author(s)
Guex-Crosier  Y., Chamot  L., Zografos  L.
ISSN
0023-2165 (Print)
Publication state
Published
Issued date
03/2003
Volume
220
Number
3
Pages
193-5
Notes
Case Reports
Journal Article --- Old month value: Mar
Abstract
BACKGROUND: We report the rare case of a chorioretinitis occurring after intravesical BCG instillation to cure in situ carcinoma. HISTORY AND SIGNS: A 57-year-old man was treated for bladder carcinoma with BCG instillations. Visual acuity was 20/20 in the right eye and 20/40 in the left eye. Bilateral chorioretinitis was discovered three months after initiation of intravesical BCG therapy. THERAPY AND OUTCOME: No progression of ocular lesions could be seen after a 6 months therapy with rifampicin, isoniazide and ethambutol. CONCLUSIONS: BCG chorioretinitis is a rare complication that can be seen after intravesical BCG therapy. BCG is a live attenuated strain of Mycobacterium bovis. Two mechanisms can be proposed as the origin of ocular inflammation: a local immune response or a direct choroidal mycobacterial infection.
Keywords
Adjuvants, Immunologic/administration & dosage/*adverse effects Antitubercular Agents/administration & dosage BCG Vaccine/administration & dosage/*adverse effects Carcinoma in Situ/*drug therapy Chorioretinitis/diagnosis/drug therapy/*etiology Drug Therapy, Combination Fluorescein Angiography Follow-Up Studies Humans Male Middle Aged Tuberculosis, Ocular/diagnosis/drug therapy/etiology Urinary Bladder Neoplasms/*drug therapy
Pubmed
Web of science
Create date
28/01/2008 13:09
Last modification date
20/08/2019 14:58
Usage data