Elevated hepatocyte paraffin 1 and neprilysin expression in hepatocellular carcinoma are correlated with longer survival.

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Serval ID
serval:BIB_9633D0FDC5AD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Elevated hepatocyte paraffin 1 and neprilysin expression in hepatocellular carcinoma are correlated with longer survival.
Journal
Virchows Archiv
Author(s)
Mondada D., Bosman F.T., Fontolliet C., Seelentag W.K.
ISSN
0945-6317
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
448
Number
1
Pages
35-45
Language
english
Abstract
Hepatocyte paraffin 1 (Hep Par 1) and neprilysin (CD10) are well-known markers of hepatocellular carcinoma (HCC). To assess their potential prognostic role, we conducted a retrospective analysis of 97 formalin-fixed and paraffin-embedded HCC from patients treated by surgery with curative intent, using standard immunohistochemical procedures and semiquantitative analysis. Strong Hep Par 1 expression and canalicular CD10 staining pattern were significantly correlated with smaller tumor size (p=0.007 and 0.04, respectively). On univariate analysis, longer overall survival was observed in patients with strong Hep Par 1 expression (p=0.0005) and in patients with a CD10can staining pattern (p=0.02). On multivariate analysis, the combined immunohistochemical score (CIS) obtained by addition of Hep Par 1 and CD10can scores and subtraction of cytoplasmic CD10 score was retained as the single most important prognostic factor (p=0.001). Patients with a CIS <4 had a 3.5-fold increased risk of death, as compared to those with a CIS >or=4. In conclusion, strong Hep Par 1 expression, presence of CD10can labeling, and absence of CD10cyt staining are favorable prognostic factors in HCC, which can be easily combined into a single immunohistochemical score for routine clinical use.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Carcinoma, Hepatocellular, Female, Humans, Immunohistochemistry, Liver Neoplasms, Male, Middle Aged, Neprilysin, Prognosis, Retrospective Studies, Survival Analysis, Tumor Markers, Biological
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 18:35
Last modification date
25/09/2019 6:10
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