Effects of single doses of the converting enzyme inhibitor cilazapril in normal volunteers
Details
Serval ID
serval:BIB_9627CE8AD9EA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of single doses of the converting enzyme inhibitor cilazapril in normal volunteers
Journal
Journal of Cardiovascular Pharmacology
ISSN
0160-2446 (Print)
Publication state
Published
Issued date
01/1987
Volume
9
Number
1
Pages
26-31
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
The new converting enzyme inhibitor cilazapril, or RO 31-2848, was evaluated in 14 healthy male volunteers. In a pilot study in two subjects, the inhibiting capacity of single oral doses of 5 and 10 mg on the pressure and heart rate response to exogenous angiotensin I was assessed. Both doses reduced the blood pressure response to angiotensin I to 10% of control within 45 min and for the 4 h tested. In the main study, 12 volunteers each received two single oral doses of cilazapril at a 2-week interval, and plasma converting enzyme and renin activity, blood angiotensin I, plasma immunoreactive angiotensin II and aldosterone were measured serially. Single doses of 1.25, 2.5, 5, and 10 mg of cilazapril were tested in groups of six subjects each. All doses inhibited plasma converting enzyme activity by 90% for at least 8 h and induced the expected pattern of changes of the renin-angiotensin-aldosterone system. Only slight dose-dependent variations in the effect were observed. Basic heart rate and blood pressure were not altered by any of the doses, which all were well tolerated. These data suggest that cilazapril is a very potent and long-acting new converting enzyme inhibitor.
Keywords
Angiotensin I/pharmacology
Angiotensin II/blood
*Angiotensin-Converting Enzyme Inhibitors
Blood Pressure/drug effects
Cilazapril
Dose-Response Relationship, Drug
Heart Rate/drug effects
Humans
Male
Pyridazines/*pharmacology
Pubmed
Create date
05/03/2008 16:41
Last modification date
20/08/2019 14:58