Psychological trauma occurring during adolescence is associated with an increased risk of greater waist circumference in Early Psychosis patients treated with psychotropic medication.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_9615E0192FAB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Psychological trauma occurring during adolescence is associated with an increased risk of greater waist circumference in Early Psychosis patients treated with psychotropic medication.
Journal
PloS one
Author(s)
Alameda L., Levier A., Gholam-Rezaee M., Golay P., Vandenberghe F., Delacretaz A., Baumann P., Glatard A., Dubath C., Herane-Vives A., Rodriguez V., Solida A., Do K.Q., Eap C.B., Conus P.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
15
Number
12
Pages
e0242569
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
It has been suggested that exposure to Childhood Trauma [CT] may play a role in the risk of obesity in Early Psychosis [EP] patients; however, whether this is independently of age at exposure to CT and the medication profile has yet to be investigated.
113 EP-patients aged 18-35 were recruited from the Treatment and Early Intervention in Psychosis Program [TIPP-Lausanne]. Body Mass Index [BMI], Weight Gain [WG] and Waist Circumference [WC] were measured prospectively at baseline and after 1, 2, 3, 6 and 12 months of weight gain inducing psychotropic treatment. Patients were classified as Early-Trauma and Late-Trauma if the exposure had occurred before age 12 or between ages 12 and 16 respectively. Generalized Linear Mixed-Models were adjusted for age, sex, socioeconomic status, baseline BMI, medication and for diagnosis of depression.
Late-Trauma patients, when compared to Non-Trauma patients showed greater WCs during the follow-up [p = 0.013]. No differences were found in any of the other follow-up measures.
Exposition to CT during adolescence in EP-patients treated with psychotropic medication is associated with greater WC during the early phase of the disease. Further investigation exploring mechanisms underlying the interactions between peripubertal stress, corticoids responsiveness and a subsequent increase of abdominal adiposity is warranted.
Keywords
General Biochemistry, Genetics and Molecular Biology, General Agricultural and Biological Sciences, General Medicine
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation
Create date
09/11/2020 9:28
Last modification date
06/01/2021 7:25
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