Comparing two basic subtypes in OCD across three large community samples: a pure compulsive versus a mixed obsessive-compulsive subtype.

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State: Public
Version: author
Serval ID
serval:BIB_961580FC6BD3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Comparing two basic subtypes in OCD across three large community samples: a pure compulsive versus a mixed obsessive-compulsive subtype.
Journal
European Archives of Psychiatry and Clinical Neuroscience
Author(s)
Rodgers S., Ajdacic-Gross V., Kawohl W., Müller M., Rössler W., Hengartner M.P., Castelao E., Vandeleur C., Angst J., Preisig M.
ISSN
1433-8491 (Electronic)
ISSN-L
0940-1334
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
265
Number
8
Pages
719-734
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Due to its heterogeneous phenomenology, obsessive-compulsive disorder (OCD) has been subtyped. However, these subtypes are not mutually exclusive. This study presents an alternative subtyping approach by deriving non-overlapping OCD subtypes. A pure compulsive and a mixed obsessive-compulsive subtype (including subjects manifesting obsessions with/without compulsions) were analyzed with respect to a broad pattern of psychosocial risk factors and comorbid syndromes/diagnoses in three representative Swiss community samples: the Zurich Study (n = 591), the ZInEP sample (n = 1500), and the PsyCoLaus sample (n = 3720). A selection of comorbidities was examined in a pooled database. Odds ratios were derived from logistic regressions and, in the analysis of pooled data, multilevel models. The pure compulsive subtype showed a lower age of onset and was characterized by few associations with psychosocial risk factors. The higher social popularity of the pure compulsive subjects and their families was remarkable. Comorbidities within the pure compulsive subtype were mainly restricted to phobias. In contrast, the mixed obsessive-compulsive subtype had a higher prevalence and was associated with various childhood adversities, more familial burden, and numerous comorbid disorders, including disorders characterized by high impulsivity. The current comparison study across three representative community surveys presented two basic, distinct OCD subtypes associated with differing psychosocial impairment. Such highly specific subtypes offer the opportunity to learn about pathophysiological mechanisms specifically involved in OCD.
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Web of science
Create date
29/10/2015 12:04
Last modification date
20/08/2019 15:58
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