Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_961363B69EFE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa.
Journal
Science Advances
Author(s)
Ren G., Zhang X., Li Y., Ridout K., Serrano-Serrano M.L., Yang Y., Liu A., Ravikanth G., Nawaz M.A., Mumtaz A.S., Salamin N., Fumagalli L.
ISSN
2375-2548 (Electronic)
ISSN-L
2375-2548
Publication state
Published
Issued date
07/2021
Peer-reviewed
Oui
Volume
7
Number
29
Pages
eabg2286
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 accessions from worldwide origins. We show that C. sativa was first domesticated in early Neolithic times in East Asia and that all current hemp and drug cultivars diverged from an ancestral gene pool currently represented by feral plants and landraces in China. We identified candidate genes associated with traits differentiating hemp and drug cultivars, including branching pattern and cellulose/lignin biosynthesis. We also found evidence for loss of function of genes involved in the synthesis of the two major biochemically competing cannabinoids during selection for increased fiber production or psychoactive properties. Our results provide a unique global view of the domestication of C. sativa and offer valuable genomic resources for ongoing functional and molecular breeding research.
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / 31003A_130234
Create date
24/07/2021 12:41
Last modification date
07/09/2021 6:36
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