Ocular gene therapy: a review of nonviral strategies.

Details

Serval ID
serval:BIB_960F42A5516E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Ocular gene therapy: a review of nonviral strategies.
Journal
Molecular Vision
Author(s)
Andrieu-Soler C., Bejjani R.A., de Bizemont T., Normand N., BenEzra D., Behar-Cohen F.
ISSN
1090-0535 (Electronic)
ISSN-L
1090-0535
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
12
Pages
1334-1347
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: epublish
Abstract
Along with viral vectors, non-viral strategies have been developed in order to efficiently deliver nucleic acids to ocular cells. During the last decade, we have observed that the outcome of these non-viral delivery systems depends on the genetic material used, the targeted tissue or cells, the expected effect duration, and the routes of administration. Assessment of efficiency has been evaluated in normal eyes or in animal models of ocular diseases. The chemical and physical methods that have been adapted for the delivery of nucleic acids to ocular tissues are highlighted and discussed in this review. Also, the results obtained with different non-viral strategies from their initial conception to their present development are summarized. At the present, selective targeting of ocular tissues and cells can be achieved using the most yielding route of administration to the eye in combination with an appropriate drug delivery technique.
Keywords
Animals, Eye Diseases/therapy, Genetic Therapy/methods, Humans
Pubmed
Web of science
Create date
29/08/2013 15:18
Last modification date
20/08/2019 14:58
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