A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS.

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State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_95F798FD2EB3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS.
Journal
The Journal of experimental medicine
Author(s)
Maccari M.E., Fuchs S., Kury P., Andrieux G., Völkl S., Bengsch B., Lorenz M.R., Heeg M., Rohr J., Jägle S., Castro C.N., Groß M., Warthorst U., König C., Fuchs I., Speckmann C., Thalhammer J., Kapp F.G., Seidel M.G., Dückers G., Schönberger S., Schütz C., Führer M., Kobbe R., Holzinger D., Klemann C., Smisek P., Owens S., Horneff G., Kolb R., Naumann-Bartsch N., Miano M., Staniek J., Rizzi M., Kalina T., Schneider P., Erxleben A., Backofen R., Ekici A., Niemeyer C.M., Warnatz K., Grimbacher B., Eibel H., Mackensen A., Frei A.P., Schwarz K., Boerries M., Ehl S., Rensing-Ehl A.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Publication state
Published
Issued date
01/02/2021
Peer-reviewed
Oui
Volume
218
Number
2
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease.
Pubmed
Create date
16/11/2020 14:38
Last modification date
18/12/2020 7:09
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