Biomarkers of immune tolerance in liver transplantation.

Details

Serval ID
serval:BIB_95E6F3A30339
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Biomarkers of immune tolerance in liver transplantation.
Journal
Human immunology
Author(s)
Vionnet J., Sánchez-Fueyo A.
ISSN
1879-1166 (Electronic)
ISSN-L
0198-8859
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
79
Number
5
Pages
388-394
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The liver exhibits intrinsic immune tolerogenic properties that contribute to a unique propensity toward spontaneous acceptance when transplanted, both in animal models and in humans. Thus, in contrast to what happens after transplantation of other solid organs, several years following liver transplantation a significant subset of patients are capable of maintaining normal allograft function with histological integrity in the absence of immunosuppressive drug treatment. Significant efforts have been put into identifying sensitive and specific biomarkers of tolerance in order to stratify liver transplant recipients according to their need for immunosuppressive medication and their likelihood of being able to completely discontinue it. These biomarkers are currently being validated in prospective clinical trials of immunosuppression withdrawal both in Europe and in the United States. These studies have the potential to transform the clinical management of liver transplant recipients by mitigating, at least in part, the burden of lifelong immunosuppression.
Keywords
Allografts/immunology, Allografts/metabolism, Allografts/pathology, Animals, Biomarkers/metabolism, Humans, Immune Tolerance/drug effects, Immune Tolerance/genetics, Immune Tolerance/immunology, Immunosuppressive Agents/pharmacology, Immunosuppressive Agents/therapeutic use, Liver/immunology, Liver/metabolism, Liver/pathology, Liver Transplantation, Prospective Studies, Transplantation Tolerance/genetics, Transplantation Tolerance/immunology, Biomarkers, Immunosuppression withdrawal, Immunotolerance, LT
Pubmed
Web of science
Create date
01/03/2018 18:33
Last modification date
20/08/2019 14:58
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