Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes.
Details
Serval ID
serval:BIB_95E06884F11E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes.
Journal
Nature communications
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
10/05/2021
Peer-reviewed
Oui
Volume
12
Number
1
Pages
2439
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
Chromatin compartmentalization reflects biological activity. However, inference of chromatin sub-compartments and compartment domains from chromosome conformation capture (Hi-C) experiments is limited by data resolution. As a result, these have been characterized only in a few cell types and systematic comparisons across multiple tissues and conditions are missing. Here, we present Calder, an algorithmic approach that enables the identification of multi-scale sub-compartments at variable data resolution. Calder allows to infer and compare chromatin sub-compartments and compartment domains in >100 cell lines. Our results reveal sub-compartments enriched for poised chromatin states and undergoing spatial repositioning during lineage differentiation and oncogenic transformation.
Pubmed
Open Access
Yes
Create date
19/05/2021 14:33
Last modification date
12/01/2022 7:12