Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus.

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Serval ID
serval:BIB_9567E0F4BC9B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus.
Journal
Journal of Infectious Diseases
Author(s)
Misstear K., McNeela E.A., Murphy A.G., Geoghegan J.A., O'Keeffe K.M., Fox J., Chan K., Heuking S., Collin N., Foster T.J., McLoughlin R.M., Lavelle E.C.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
209
Number
9
Pages
1479-1484
Language
english
Abstract
Despite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles loaded with Staphylococcus aureus antigen protects against acute systemic S. aureus infection in the absence of any antigen-specific antibodies. These findings can help inform future developments in staphylococcal vaccine development and studies into the requirements for protective immunity against S. aureus.
Keywords
vaccine, Staphylococcus aureus, cellular immunity, mucosal, adjuvant, nanoparticle
Pubmed
Web of science
Open Access
Yes
Create date
13/01/2014 13:57
Last modification date
20/08/2019 14:57
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