Assessment of Macular Vasculature of Children With Sickle Cell Disease Compared to that of Healthy Controls Using Optical Coherence Tomography Angiography

Details

Serval ID
serval:BIB_955690B5B3EC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assessment of Macular Vasculature of Children With Sickle Cell Disease Compared to that of Healthy Controls Using Optical Coherence Tomography Angiography
Journal
Retina
Author(s)
Roemer S., Bergin C., Kaeser P.F., Ambresin A.
ISSN
1539-2864 (Electronic)
ISSN-L
0275-004X
Publication state
Published
Issued date
12/2019
Peer-reviewed
Oui
Volume
39
Number
12
Pages
2384-2391
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
This study aims at describing the macular vascular features of the eyes of pediatric patients with the homozygous form of sickle cell disease (SCD) using optical coherence tomography angiography.
This is a retrospective case series of eyes of pediatric patients with SCD, race- and age-matched to those of healthy individuals. Using optical coherence tomography angiography images of superficial capillary plexus and deep capillary plexus, the nonflow area, vascular density, and foveal avascular zone were measured. The remodeled microvascular foveal architectures obtained on optical coherence tomography angiography and fluorescein angiography were compared.
A total of 19 eyes of patients with SCD and 18 eyes of race-matched healthy controls were examined. The best-corrected visual acuity ranged from 75 to 85 letters in all cases. In the SCD series, 8 eyes displayed signs of retinopathy on funduscopy. The foveal avascular zone was significantly enlarged, the foveal vascular density was 8% lower, and there were more perifoveal vascular alterations in the eyes of patients with SCD compared to those of controls.
The foveal vascular density was significantly reduced and area of the foveal avascular zone was significantly increased in the eyes of patients with SCD. Consistent architectural changes in the perifoveal capillaries were also observed in the pediatric patients with SCD.
Pubmed
Web of science
Create date
18/11/2018 16:40
Last modification date
08/02/2020 6:17
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