A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.

Details

Serval ID
serval:BIB_95271BD54B2D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
Journal
Human molecular genetics
Author(s)
Sung Y.J., de Las Fuentes L., Winkler T.W., Chasman D.I., Bentley A.R., Kraja A.T., Ntalla I., Warren H.R., Guo X., Schwander K., Manning A.K., Brown M.R., Aschard H., Feitosa M.F., Franceschini N., Lu Y., Cheng C.Y., Sim X., Vojinovic D., Marten J., Musani S.K., Kilpeläinen T.O., Richard M.A., Aslibekyan S., Bartz T.M., Dorajoo R., Li C., Liu Y., Rankinen T., Smith A.V., Tajuddin S.M., Tayo B.O., Zhao W., Zhou Y., Matoba N., Sofer T., Alver M., Amini M., Boissel M., Chai J.F., Chen X., Divers J., Gandin I., Gao C., Giulianini F., Goel A., Harris S.E., Hartwig F.P., He M., Horimoto ARVR, Hsu F.C., Jackson A.U., Kammerer C.M., Kasturiratne A., Komulainen P., Kühnel B., Leander K., Lee W.J., Lin K.H., Luan J., Lyytikäinen L.P., McKenzie C.A., Nelson C.P., Noordam R., Scott R.A., Sheu WHH, Stančáková A., Takeuchi F., van der Most P.J., Varga T.V., Waken R.J., Wang H., Wang Y., Ware E.B., Weiss S., Wen W., Yanek L.R., Zhang W., Zhao J.H., Afaq S., Alfred T., Amin N., Arking D.E., Aung T., Barr R.G., Bielak L.F., Boerwinkle E., Bottinger E.P., Braund P.S., Brody J.A., Broeckel U., Cade B., Campbell A., Canouil M., Chakravarti A., Cocca M., Collins F.S., Connell J.M., de Mutsert R., de Silva H.J., Dörr M., Duan Q., Eaton C.B., Ehret G., Evangelou E., Faul J.D., Forouhi N.G., Franco O.H., Friedlander Y., Gao H., Gigante B., Gu C.C., Gupta P., Hagenaars S.P., Harris T.B., He J., Heikkinen S., Heng C.K., Hofman A., Howard B.V., Hunt S.C., Irvin M.R., Jia Y., Katsuya T., Kaufman J., Kerrison N.D., Khor C.C., Koh W.P., Koistinen H.A., Kooperberg C.B., Krieger J.E., Kubo M., Kutalik Z., Kuusisto J., Lakka T.A., Langefeld C.D., Langenberg C., Launer L.J., Lee J.H., Lehne B., Levy D., Lewis C.E., Li Y., Lim S.H., Liu C.T., Liu J., Liu J., Liu Y., Loh M., Lohman K.K., Louie T., Mägi R., Matsuda K., Meitinger T., Metspalu A., Milani L., Momozawa Y., Mosley T.H., Nalls M.A., Nasri U., O'Connell J.R., Ogunniyi A., Palmas W.R., Palmer N.D., Pankow J.S., Pedersen N.L., Peters A., Peyser P.A., Polasek O., Porteous D., Raitakari O.T., Renström F., Rice T.K., Ridker P.M., Robino A., Robinson J.G., Rose L.M., Rudan I., Sabanayagam C., Salako B.L., Sandow K., Schmidt C.O., Schreiner P.J., Scott W.R., Sever P., Sims M., Sitlani C.M., Smith B.H., Smith J.A., Snieder H., Starr J.M., Strauch K., Tang H., Taylor K.D., Teo Y.Y., Tham Y.C., Uitterlinden A.G., Waldenberger M., Wang L., Wang Y.X., Wei W.B., Wilson G., Wojczynski M.K., Xiang Y.B., Yao J., Yuan J.M., Zonderman A.B., Becker D.M., Boehnke M., Bowden D.W., Chambers J.C., Chen Y.I., Weir D.R., de Faire U., Deary I.J., Esko T., Farrall M., Forrester T., Freedman B.I., Froguel P., Gasparini P., Gieger C., Horta B.L., Hung Y.J., Jonas J.B., Kato N., Kooner J.S., Laakso M., Lehtimäki T., Liang K.W., Magnusson PKE, Oldehinkel A.J., Pereira A.C., Perls T., Rauramaa R., Redline S., Rettig R., Samani N.J., Scott J., Shu X.O., van der Harst P., Wagenknecht L.E., Wareham N.J., Watkins H., Wickremasinghe A.R., Wu T., Kamatani Y., Laurie C.C., Bouchard C., Cooper R.S., Evans M.K., Gudnason V., Hixson J., Kardia SLR, Kritchevsky S.B., Psaty B.M., van Dam R.M., Arnett D.K., Mook-Kanamori D.O., Fornage M., Fox E.R., Hayward C., van Duijn C.M., Tai E.S., Wong T.Y., Loos RJF, Reiner A.P., Rotimi C.N., Bierut L.J., Zhu X., Cupples L.A., Province M.A., Rotter J.I., Franks P.W., Rice K., Elliott P., Caulfield M.J., Gauderman W.J., Munroe P.B., Rao D.C., Morrison A.C.
Working group(s)
Lifelines Cohort Study
ISSN
1460-2083 (Electronic)
ISSN-L
0964-6906
Publication state
Published
Issued date
10/04/2019
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene-smoking interaction analysis and 38 were newly identified (P < 5 × 10-8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2019 17:50
Last modification date
05/01/2020 7:18
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