Transcriptional profile of Mycobacterium tuberculosis infection in people living with HIV.

Details

Serval ID
serval:BIB_95218B748165
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transcriptional profile of Mycobacterium tuberculosis infection in people living with HIV.
Journal
iScience
Author(s)
Tepekule B., Jörimann L., Schenkel C.D., Opitz L., Tschumi J., Wolfensberger R., Neumann K., Kusejko K., Zeeb M., Boeck L., Kälin M., Notter J., Furrer H., Hoffmann M., Hirsch H.H., Calmy A., Cavassini M., Labhardt N.D., Bernasconi E., Oesch G., Metzner K.J., Braun D.L., Günthard H.F., Kouyos R.D., Duffy F., Nemeth J.
Working group(s)
Swiss HIV Cohort Study
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Publication state
Published
Issued date
15/11/2024
Peer-reviewed
Oui
Volume
27
Number
11
Pages
111228
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In people with HIV-1 (PWH), Mycobacterium tuberculosis (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals. Functional annotation identified alterations in IL-6, TNF, and KRAS pathways. Notably, MTB-related genes displayed an inverse correlation with HIV-1 viremia, at both individual and signature score levels. These findings suggest that MTB infection in PWH induces a shift in immune system activation, inversely related to HIV-1 viral load. These results may explain the observed enhanced antiretroviral control in MTB-infected PWH. This study highlights the complex interplay between MTB and HIV-1, emphasizing the importance of understanding their interaction for managing co-infections in this population.
Keywords
Health sciences, Microbiology, Transcriptomics
Pubmed
Web of science
Open Access
Yes
Create date
22/11/2024 15:38
Last modification date
26/11/2024 7:04
Usage data