Effect of propranolol and prindolol on renin secretion in normal supine man

Details

Serval ID
serval:BIB_94EC8102A623
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effect of propranolol and prindolol on renin secretion in normal supine man
Journal
Klinische Wochenschrift
Author(s)
Vetter  W., Zaruba  K., Armbruster  H., Beckerhoff  R., Vetter  H., Nussberger  J., Schmied  U., Reck  G., Fontana  A., Siegenthaler  W.
ISSN
0023-2173 (Print)
Publication state
Published
Issued date
08/1975
Volume
53
Number
15
Pages
709-11
Notes
Journal Article --- Old month value: Aug 1
Abstract
To investigate the effect of propranolol and prindolol on renin secretion plasma renin activity (PRA) was determined overnight at short-time intervals in 10 sodium-restricted normal supine subjects. 4 of them were on a 4-days medication with propranolol, 3 were rreated with prindolol and 3 were used as control group. In normal controls renin was secreted episodically and showed characteristic night-day variations. Both in propranolol and in prindolol-treated subjects secretory episodes in renin secretion either did not occur or were less frequent than in normal controls. With one exception night-day variations in renin secretion were not observed. Mean PRA values were significantly lower than in the control group (p less than 0.001). Our results show that both propranolol and prindolol lower PRA and eliminate or reduce the frequency of secretory episodes. It is concluded that the sympathetic nervous system plays an important role in regulating night-day variations and short-time fluctuations of renin secretion in normal supine man.
Keywords
Adult Circadian Rhythm Diet, Sodium-Restricted Humans Male Posture Renin/blood/*secretion Secretory Rate/drug effects Sympathetic Nervous System/physiology
Pubmed
Web of science
Create date
05/03/2008 17:41
Last modification date
03/03/2018 19:38
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